Isabel Jaco
Overview
Explore the profile of Isabel Jaco including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
1348
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0
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Recent Articles
1.
Ferretti S, Hamon J, de Kanter R, Scheufler C, Andraos-Rey R, Barbe S, et al.
Nature
. 2024 Apr;
629(8011):443-449.
PMID: 38658754
The Werner syndrome RecQ helicase WRN was identified as a synthetic lethal target in cancer cells with microsatellite instability (MSI) by several genetic screens. Despite advances in treatment with immune...
2.
Moerke C, Jaco I, Dewitz C, Muller T, Jacobsen A, Gautheron J, et al.
Cell Death Differ
. 2018 Nov;
26(9):1631-1645.
PMID: 30442947
Different forms of regulated cell death-like apoptosis and necroptosis contribute to the pathophysiology of clinical conditions including ischemia-reperfusion injury, myocardial infarction, sepsis, and multiple sclerosis. In particular, the kinase activity...
3.
Barry R, John S, Liccardi G, Tenev T, Jaco I, Chen C, et al.
Nat Commun
. 2018 Aug;
9(1):3001.
PMID: 30069026
The NLRP3 inflammasome responds to infection and tissue damage, and rapidly escalates the intensity of inflammation by activating interleukin (IL)-1β, IL-18 and cell death by pyroptosis. How the NLRP3 inflammasome...
4.
Feltham R, Jamal K, Tenev T, Liccardi G, Jaco I, Domingues C, et al.
Cell Rep
. 2018 Apr;
23(2):470-484.
PMID: 29642005
Tumor necrosis factor (TNF) is an inflammatory cytokine that can signal cell survival or cell death. The mechanisms that switch between these distinct outcomes remain poorly defined. Here, we show...
5.
Jaco I, Annibaldi A, Lalaoui N, Wilson R, Tenev T, Laurien L, et al.
Mol Cell
. 2017 May;
66(5):698-710.e5.
PMID: 28506461
TNF is an inflammatory cytokine that upon binding to its receptor, TNFR1, can drive cytokine production, cell survival, or cell death. TNFR1 stimulation causes activation of NF-κB, p38α, and its...
6.
Badie S, Escandell J, Bouwman P, Carlos A, Thanasoula M, Gallardo M, et al.
Nat Struct Mol Biol
. 2010 Nov;
17(12):1461-9.
PMID: 21076401
The tumor suppressor protein BRCA2 is a key component of the homologous recombination pathway of DNA repair, acting as the loader of RAD51 recombinase at sites of double-strand breaks. Here...
7.
Benetti R, Gonzalo S, Jaco I, Munoz P, Gonzalez S, Schoeftner S, et al.
Nat Struct Mol Biol
. 2008 Sep;
15(9):998.
PMID: 18769471
No abstract available.
8.
Jaco I, Canela A, Vera E, Blasco M
J Cell Biol
. 2008 Jun;
181(6):885-92.
PMID: 18541703
Centromeres are special structures of eukaryotic chromosomes that hold sister chromatid together and ensure proper chromosome segregation during cell division. Centromeres consist of repeated sequences, which have hindered the study...
9.
Benetti R, Gonzalo S, Jaco I, Munoz P, Gonzalez S, Schoeftner S, et al.
Nat Struct Mol Biol
. 2008 Mar;
15(3):268-79.
PMID: 18311151
Dicer initiates RNA interference by generating small RNAs involved in various silencing pathways. Dicer participates in centromeric silencing, but its role in the epigenetic regulation of other chromatin domains has...
10.
Murga M, Jaco I, Fan Y, Soria R, Martinez-Pastor B, Cuadrado M, et al.
J Cell Biol
. 2007 Sep;
178(7):1101-8.
PMID: 17893239
In response to DNA damage, chromatin undergoes a global decondensation process that has been proposed to facilitate genome surveillance. However, the impact that chromatin compaction has on the DNA damage...