Isabel Chu
Overview
Explore the profile of Isabel Chu including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
558
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Recent Articles
1.
Gazelakis K, Chu I, Martin C, Sparrow M
Intern Med J
. 2023 May;
54(1):139-148.
PMID: 37151186
Background: Inflammatory bowel disease (IBD) therapies now utilise higher doses of immunomodulatory and biologic therapies, predisposing patients to an increased risk of infections. Aims: We aimed to determine whether infections...
2.
Plompen E, Valk P, Chu I, Darwish Murad S, Plessier A, Turon F, et al.
Haematologica
. 2015 Feb;
100(6):e226-8.
PMID: 25682604
No abstract available.
3.
Das S, Bosley A, Ye X, Chan K, Chu I, Green J, et al.
J Proteome Res
. 2010 Oct;
9(12):6696-704.
PMID: 20968308
Affinity purification of protein complexes followed by identification using liquid chromatography/mass spectrometry (LC-MS/MS) is a robust method to study the fundamental process of protein interaction. Although affinity isolation reduces the...
4.
Barkan D, El Touny L, Michalowski A, Smith J, Chu I, Davis A, et al.
Cancer Res
. 2010 Jun;
70(14):5706-16.
PMID: 20570886
Breast cancer that recurs as metastatic disease many years after primary tumor resection and adjuvant therapy seems to arise from tumor cells that disseminated early in the course of disease...
5.
Chu I, Arnaout A, Loiseau S, Sun J, Seth A, McMahon C, et al.
J Clin Invest
. 2007 Jul;
117(8):2205-15.
PMID: 17627304
Estrogen drives both transcriptional activation and proteolysis of estrogen receptor alpha (ER alpha; encoded by ESR1). Here we observed variable and overlapping ESR1 mRNA levels in 200 ER alpha-negative and...
6.
Chu I, Sun J, Arnaout A, Kahn H, Hanna W, Narod S, et al.
Cell
. 2007 Jan;
128(2):281-94.
PMID: 17254967
The kinase inhibitor p27Kip1 regulates the G1 cell cycle phase. Here, we present data indicating that the oncogenic kinase Src regulates p27 stability through phosphorylation of p27 at tyrosine 74...
7.
Chu I, Blackwell K, Chen S, Slingerland J
Cancer Res
. 2005 Jan;
65(1):18-25.
PMID: 15665275
Effective treatment of estrogen receptor (ER)-positive breast cancers with tamoxifen is often curtailed by the development of drug resistance. Antiestrogen-resistant breast cancers often show increased expression of the epidermal growth...
8.
Ma N, Szmitko P, Brade A, Chu I, Lo A, Woodgett J, et al.
Cancer Gene Ther
. 2003 Dec;
11(1):52-60.
PMID: 14681726
We have previously demonstrated that protein kinase B (PKB) is a mediator of heat-induced apoptosis for human breast cancer cells. To investigate the therapeutic potential of abrogating the function of...