Irma Lemmens
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Explore the profile of Irma Lemmens including associated specialties, affiliations and a list of published articles.
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46
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3527
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Recent Articles
1.
Monnens Y, Theodoropoulou A, Rosier K, Bhalla K, Mahy A, Vanhoutte R, et al.
JCI Insight
. 2024 Jul;
9(17).
PMID: 39078710
Congenital myasthenic syndrome-22 (CMS22, OMIM 616224) is a rare genetic disorder caused by deleterious genetic variation in the prolyl endopeptidase-like (PREPL) gene. Previous reports have described patients with deletions and...
2.
Corneillie L, Lemmens I, Weening K, De Meyer A, Van Houtte F, Tavernier J, et al.
Viruses
. 2023 Dec;
15(12).
PMID: 38140653
Throughout their life cycle, viruses interact with cellular host factors, thereby influencing propagation, host range, cell tropism and pathogenesis. The hepatitis E virus (HEV) is an underestimated RNA virus in...
3.
Corneillie L, Lemmens I, Montpellier C, Ferrie M, Weening K, Van Houtte F, et al.
Cell Mol Life Sci
. 2023 Oct;
80(11):326.
PMID: 37833515
The hepatitis E virus (HEV) is an underestimated RNA virus of which the viral life cycle and pathogenicity remain partially understood and for which specific antivirals are lacking. The virus...
4.
Tang H, Spirohn K, Hu Y, Hao T, Kovacs I, Gao Y, et al.
Nat Commun
. 2023 Apr;
14(1):2162.
PMID: 37061542
Generating reference maps of interactome networks illuminates genetic studies by providing a protein-centric approach to finding new components of existing pathways, complexes, and processes. We apply state-of-the-art methods to identify...
5.
Corominas R, Yang X, Lin G, Kang S, Shen Y, Ghamsari L, et al.
Nat Commun
. 2023 Feb;
14(1):569.
PMID: 36732511
No abstract available.
6.
Van Royen T, Sedeyn K, Moschonas G, Toussaint W, Vuylsteke M, Van Haver D, et al.
J Virol
. 2022 Sep;
96(19):e0129722.
PMID: 36102648
Human respiratory syncytial virus (RSV) is the leading cause of severe acute lower respiratory tract infections in infants worldwide. Nonstructural protein NS1 of RSV modulates the host innate immune response...
7.
Rosier K, McDevitt M, Smet J, Floyd B, Verschoore M, Marcaida M, et al.
iScience
. 2021 Dec;
24(12):103460.
PMID: 34888501
Deficiency of the serine hydrolase prolyl endopeptidase-like (PREPL) causes a recessive metabolic disorder characterized by neonatal hypotonia, feeding difficulties, and growth hormone deficiency. The pathophysiology of PREPL deficiency and the...
8.
Rosa N, Ivanova H, Wagner 2nd L, Kale J, La Rovere R, Welkenhuyzen K, et al.
Cell Death Differ
. 2021 Nov;
29(4):788-805.
PMID: 34750538
Anti-apoptotic Bcl-2-family members not only act at mitochondria but also at the endoplasmic reticulum, where they impact Ca dynamics by controlling IP receptor (IPR) function. Current models propose distinct roles...
9.
Vangeel L, Janssens A, Lemmens I, Lievens S, Tavernier J, Voets T
Int J Mol Sci
. 2020 May;
21(10).
PMID: 32443528
The Ca-permeable Transient Receptor Potential channel vanilloid subfamily member 4 (TRPV4) is involved in a broad range of physiological processes, including the regulation of systemic osmotic pressure, bone resorption, vascular...
10.
Luck K, Kim D, Lambourne L, Spirohn K, Begg B, Bian W, et al.
Nature
. 2020 Apr;
580(7803):402-408.
PMID: 32296183
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships. Here we present a human 'all-by-all' reference interactome map of human...