Iris Muller
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Explore the profile of Iris Muller including associated specialties, affiliations and a list of published articles.
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70
Citations
1576
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Recent Articles
11.
Appenzeller F, Gawaz M, Muller I
Case Rep Cardiol
. 2022 May;
2022:5640965.
PMID: 35496656
Both COVID-19 disease and cocaine consumption have prothrombotic and hypercoagulable effects and are associated with increased risk of cardiovascular events. We report the case of a patient with acute myocardial...
12.
Garland W, Muller I, Wu M, Schmid M, Imamura K, Rib L, et al.
Mol Cell
. 2022 Mar;
82(9):1691-1707.e8.
PMID: 35349793
Transposable elements (TEs) are widespread genetic parasites known to be kept under tight transcriptional control. Here, we describe a functional connection between the mouse-orthologous "nuclear exosome targeting" (NEXT) and "human...
13.
Basili D, Reynolds J, Houghton J, Malcomber S, Chambers B, Liddell M, et al.
Chem Res Toxicol
. 2022 Mar;
35(4):670-683.
PMID: 35333521
Estimation of points of departure (PoDs) from high-throughput transcriptomic data (HTTr) represents a key step in the development of next-generation risk assessment (NGRA). Current approaches mainly rely on single key...
14.
Rajagopal R, Baltazar M, Carmichael P, Dent M, Head J, Li H, et al.
Front Toxicol
. 2022 Mar;
4:838466.
PMID: 35295212
New Approach Methodologies (NAMs) promise to offer a unique opportunity to enable human-relevant safety decisions to be made without the need for animal testing in the context of exposure-driven Next...
15.
Nitsche K, Muller I, Malcomber S, Carmichael P, Bouwmeester H
Arch Toxicol
. 2022 Feb;
96(3):711-741.
PMID: 35103818
Organ-on-chip (OoC) technology is full of engineering and biological challenges, but it has the potential to revolutionize the Next-Generation Risk Assessment of novel ingredients for consumer products and chemicals. A...
16.
Lin J, Guo D, Liu H, Zhou W, Wang C, Muller I, et al.
Cancer Immunol Res
. 2021 Dec;
9(12):1413-1424.
PMID: 34848497
The tumor immune microenvironment is influenced by the epigenetic landscape of the tumor. Here, we have identified the SETDB1-TRIM28 complex as a critical suppressor of antitumor immunity. An epigenetic CRISPR-Cas9...
17.
Appenzeller F, Schmehl J, Gawaz M, Muller I
Hamostaseologie
. 2021 Sep;
41(5):400-402.
PMID: 34492713
In this case report we present a previously healthy 21-year-old male with extensive thromboembolism in the setting of asymptomatic COVID-19 infection and heterozygous factor V Leiden mutation with no additional...
18.
Madencioglu D, Caliskan G, Yuanxiang P, Rehberg K, Demiray Y, Kul E, et al.
iScience
. 2021 Aug;
24(8):102868.
PMID: 34381982
Duplications and deletions of short chromosomal fragments are increasingly recognized as the cause for rare neurodevelopmental conditions and disorders. The gene encodes a protein kinase important for neuronal development and...
19.
Muller I, Moroni A, Shlyueva D, Sahadevan S, Schoof E, Radzisheuskaya A, et al.
Nat Commun
. 2021 May;
12(1):3034.
PMID: 34031396
Deciphering the mechanisms that control the pluripotent ground state is key for understanding embryonic development. Nonetheless, the epigenetic regulation of ground-state mouse embryonic stem cells (mESCs) is not fully understood....
20.
Wang X, Friesen E, Muller I, Lemieux M, Dukart R, Maia I, et al.
Bio Protoc
. 2021 Mar;
10(9):e3615.
PMID: 33659578
CRISPR-Cas9 technology has transformed the ability to edit genomic sequences and control gene expression with unprecedented ease and scale. However, precise genomic insertions of coding sequences using this technology remain...