Irina Surgucheva
Overview
Explore the profile of Irina Surgucheva including associated specialties, affiliations and a list of published articles.
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14
Citations
379
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Recent Articles
1.
Surguchov A, Surgucheva I, Sharma M, Sharma R, Singh V
Front Neurol
. 2017 Feb;
8:3.
PMID: 28149289
Epilepsy is a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. In the last two decades, numerous gene defects underlying different forms of epilepsy have...
2.
Surgucheva I, He S, Rich M, Sharma R, Ninkina N, Stahel P, et al.
Mol Cell Neurosci
. 2014 Dec;
63:114-23.
PMID: 25447944
Synucleins are small prone to aggregate proteins associated with several neurodegenerative diseases (NDDs), however their role in traumatic brain injury (TBI) is an emerging area of investigation. Using in vitro...
3.
Surgucheva I, Newell K, Burns J, Surguchov A
Acta Neuropathol Commun
. 2014 Sep;
2:132.
PMID: 25209836
Introduction: Several neurodegenerative diseases are classified as proteopathies as they are associated with the aggregation of misfolded proteins. Synucleinopathies are a group of neurodegenerative disorders associated with abnormal deposition of...
4.
Surgucheva I, Gunewardena S, Rao H, Surguchov A
PLoS One
. 2013 Sep;
8(9):e73786.
PMID: 24040069
γ-Synuclein is a member of the synucleins family of small proteins, which consists of three members:α, β- and γ-synuclein. γ-Synuclein is abnormally expressed in a high percentage of advanced and...
5.
Surgucheva I, Sharov V, Surguchov A
Biochemistry
. 2012 May;
51(23):4743-54.
PMID: 22620680
Protein misfolding and aggregation is a ubiquitous phenomenon associated with a wide range of diseases. The synuclein family comprises three small naturally unfolded proteins implicated in neurodegenerative diseases and some...
6.
Surgucheva I, Surguchov A
Mol Vis
. 2011 Dec;
17:2878-88.
PMID: 22128235
Purpose: Primary open-angle glaucoma (POAG), which is the most common form of glaucoma, has been associated with a heterogeneous genetic component. A genome-wide association study has identified a common sequence...
7.
Surgucheva I, Chidambaram K, Willoughby D, Surguchov A
J Ocul Biol Dis Infor
. 2011 Aug;
3(2):41-52.
PMID: 21818406
Retinal ganglion cells apoptosis is linked to matrix metalloproteinase 9 (MMP-9) controlled changes of extracellular matrix. Abnormal expression of MMP-9 is associated with glaucomatous alterations. Thus, the knowledge of MMP-9...
8.
Surgucheva I, Shestopalov V, Surguchov A
J Biol Chem
. 2008 Oct;
283(52):36377-85.
PMID: 18936092
gamma-Synuclein (Syn G) is highly expressed in retinal ganglion cells and the loss of these cells in glaucoma is associated with significant reduction of the intracellular Syn G level. However,...
9.
Surgucheva I, Weisman A, Goldberg J, Shnyra A, Surguchov A
Mol Vis
. 2008 Aug;
14:1540-8.
PMID: 18728752
Purpose: Previous studies have described gamma-synuclein as a protein highly expressed in retinal ganglion cells (RGCs), and a loss of RGCs correlates with a downregulation of gamma-synuclein gene expression in...
10.
Surgucheva I, Surguchov A
J Mol Neurosci
. 2008 May;
35(3):267-71.
PMID: 18498014
Gamma-synuclein, also referred to as breast-cancer-specific gene 1, is the third member of the neuronal protein family synuclein. Synucleins attracted the attention of many investigators because of their role in...