Irina M Shapiro
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Explore the profile of Irina M Shapiro including associated specialties, affiliations and a list of published articles.
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8
Citations
1218
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Recent Articles
1.
Kolev V, Tam W, Wright Q, McDermott S, Vidal C, Shapiro I, et al.
Oncotarget
. 2017 Sep;
8(31):51733-51747.
PMID: 28881682
Because cancer stem cells (CSCs) have been implicated in chemo-resistance, metastasis and tumor recurrence, therapeutic targeting of CSCs holds promise to address these clinical challenges to cancer treatment. VS-4718 and...
2.
Begum A, Ewachiw T, Jung C, Huang A, Norberg K, Marchionni L, et al.
PLoS One
. 2017 Jul;
12(7):e0180181.
PMID: 28692661
Cancer stem cells (CSCs) play an important role in the clonogenic growth and metastasis of pancreatic ductal adenocarcinoma (PDAC). A hallmark of PDAC is the desmoplastic reaction, but the impact...
3.
Jiang H, Hegde S, Knolhoff B, Zhu Y, Herndon J, Meyer M, et al.
Nat Med
. 2016 Jul;
22(8):851-60.
PMID: 27376576
Single-agent immunotherapy has achieved limited clinical benefit to date in patients with pancreatic ductal adenocarcinoma (PDAC). This may be a result of the presence of a uniquely immunosuppressive tumor microenvironment...
4.
Churchman M, Evans K, Richmond J, Robbins A, Jones L, Shapiro I, et al.
JCI Insight
. 2016 Apr;
1(4).
PMID: 27123491
BCR-ABL1 B progenitor acute lymphoblastic leukemia (Ph B-ALL) is an aggressive disease that frequently responds poorly to currently available therapies. Alterations in , which encodes the lymphoid transcription factor Ikaros,...
5.
Kolev V, Wright Q, Vidal C, Ring J, Shapiro I, Ricono J, et al.
Cancer Res
. 2014 Nov;
75(2):446-55.
PMID: 25432176
Cancer stem cells (CSC) have been implicated in disease recurrence, metastasis, and therapeutic resistance, but effective targeting strategies for these cells are still wanting. VS-5584 is a potent and selective...
6.
Shapiro I, Kolev V, Vidal C, Kadariya Y, Ring J, Wright Q, et al.
Sci Transl Med
. 2014 May;
6(237):237ra68.
PMID: 24848258
The goal of targeted therapy is to match a selective drug with a genetic lesion that predicts for drug sensitivity. In a diverse panel of cancer cell lines, we found...
7.
Menges C, Kadariya Y, Altomare D, Talarchek J, Neumann-Domer E, Wu Y, et al.
Cancer Res
. 2013 Dec;
74(4):1261-1271.
PMID: 24371224
Malignant mesothelioma is a highly aggressive, asbestos-related cancer frequently marked by mutations of both NF2 and CDKN2A. We demonstrate that germline knockout of one allele of each of these genes...
8.
Shapiro I, Cheng A, Flytzanis N, Balsamo M, Condeelis J, Oktay M, et al.
PLoS Genet
. 2011 Aug;
7(8):e1002218.
PMID: 21876675
Epithelial-mesenchymal transition (EMT), a mechanism important for embryonic development, plays a critical role during malignant transformation. While much is known about transcriptional regulation of EMT, alternative splicing of several genes...