Irina Khrebtukova
Overview
Explore the profile of Irina Khrebtukova including associated specialties, affiliations and a list of published articles.
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26
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7175
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Recent Articles
1.
Cromer M, Barsan V, Jaeger E, Wang M, Hampton J, Chen F, et al.
Nat Commun
. 2022 Aug;
13(1):4724.
PMID: 35953477
As CRISPR-based therapies enter the clinic, evaluation of safety remains a critical and active area of study. Here, we employ a clinical next generation sequencing (NGS) workflow to achieve high...
2.
Ho R, Workman M, Mathkar P, Wu K, Kim K, ORourke J, et al.
Cell Syst
. 2020 Dec;
12(2):159-175.e9.
PMID: 33382996
Induced pluripotent stem cell (iPSC)-derived neural cultures from amyotrophic lateral sclerosis (ALS) patients can model disease phenotypes. However, heterogeneity arising from genetic and experimental variability limits their utility, impacting reproducibility...
3.
Ramskold D, Luo S, Wang Y, Li R, Deng Q, Faridani O, et al.
Nat Biotechnol
. 2020 Feb;
38(3):374.
PMID: 32015550
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
4.
Rienhoff Jr H, Yeo C, Morissette R, Khrebtukova I, Melnick J, Luo S, et al.
Am J Med Genet A
. 2013 Jul;
161A(8):2040-6.
PMID: 23824657
The transforming growth factor β (TGF-β) family of growth factors are key regulators of mammalian development and their dysregulation is implicated in human disease, notably, heritable vasculopathies including Marfan (MFS,...
5.
Schuh A, Becq J, Humphray S, Alexa A, Burns A, Clifford R, et al.
Blood
. 2012 Aug;
120(20):4191-6.
PMID: 22915640
Chronic lymphocytic leukemia is characterized by relapse after treatment and chemotherapy resistance. Similarly, in other malignancies leukemia cells accumulate mutations during growth, forming heterogeneous cell populations that are subject to...
6.
Ramskold D, Luo S, Wang Y, Li R, Deng Q, Faridani O, et al.
Nat Biotechnol
. 2012 Jul;
30(8):777-82.
PMID: 22820318
Genome-wide transcriptome analyses are routinely used to monitor tissue-, disease- and cell type–specific gene expression, but it has been technically challenging to generate expression profiles from single cells. Here we...
7.
Akalin A, Garrett-Bakelman F, Kormaksson M, Busuttil J, Zhang L, Khrebtukova I, et al.
PLoS Genet
. 2012 Jun;
8(6):e1002781.
PMID: 22737091
We have developed an enhanced form of reduced representation bisulfite sequencing with extended genomic coverage, which resulted in greater capture of DNA methylation information of regions lying outside of traditional...
8.
Hartung T, Zhang L, Kanwar R, Khrebtukova I, Reinhardt M, Wang C, et al.
Epigenetics
. 2012 Mar;
7(5):421-8.
PMID: 22415013
DNA methylation can control some CpG-poor genes but unbiased studies have not found a consistent genome-wide association with gene activity outside of CpG islands or shores possibly due to use...
9.
Murchison E, Schulz-Trieglaff O, Ning Z, Alexandrov L, Bauer M, Fu B, et al.
Cell
. 2012 Feb;
148(4):780-91.
PMID: 22341448
The Tasmanian devil (Sarcophilus harrisii), the largest marsupial carnivore, is endangered due to a transmissible facial cancer spread by direct transfer of living cancer cells through biting. Here we describe...
10.
Nutiu R, Friedman R, Luo S, Khrebtukova I, Silva D, Li R, et al.
Nat Biotechnol
. 2011 Jun;
29(7):659-64.
PMID: 21706015
Several methods for characterizing DNA-protein interactions are available, but none have demonstrated both high throughput and quantitative measurement of affinity. Here we describe 'high-throughput sequencing'-'fluorescent ligand interaction profiling' (HiTS-FLIP), a...