Irene Miranda-Lorenzo
Overview
Explore the profile of Irene Miranda-Lorenzo including associated specialties, affiliations and a list of published articles.
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9
Citations
610
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Recent Articles
1.
Vieira de Castro J, Goncalves C, Martins E, Miranda-Lorenzo I, Cerqueira M, Longatto-Filho A, et al.
Cancers (Basel)
. 2021 Mar;
13(4).
PMID: 33669350
The identification of cancer stem cells (CSCs), which are implicated in tumor initiation, progression, therapy resistance, and relapse, is of great biological and clinical relevance. In glioblastoma (GBM), this is...
2.
Cioffi M, Trabulo S, Sanchez-Ripoll Y, Miranda-Lorenzo I, Lonardo E, Dorado J, et al.
Gut
. 2015 Apr;
64(12):1936-48.
PMID: 25887381
Objective: Cancer stem cells (CSCs) represent the root of many solid cancers including pancreatic ductal adenocarcinoma, are highly chemoresistant and represent the cellular source for disease relapse. However the mechanisms...
3.
Sainz Jr B, Alcala S, Garcia E, Sanchez-Ripoll Y, Azevedo M, Cioffi M, et al.
Gut
. 2015 Apr;
64(12):1921-35.
PMID: 25841238
Objectives: The tumour stroma/microenvironment not only provides structural support for tumour development, but more importantly it provides cues to cancer stem cells (CSCs) that regulate their self-renewal and metastatic potential....
4.
Miranda-Lorenzo I, Dorado J, Lonardo E, Alcala S, Serrano A, Clausell-Tormos J, et al.
Nat Methods
. 2014 Sep;
11(11):1161-9.
PMID: 25262208
Cancer stem cells (CSCs) are thought to drive tumor growth, metastasis and chemoresistance. Although surface markers such as CD133 and CD44 have been successfully used to isolate CSCs, their expression...
5.
Balic A, Sorensen M, Trabulo S, Sainz Jr B, Cioffi M, Vieira C, et al.
Mol Cancer Ther
. 2014 May;
13(7):1758-71.
PMID: 24785258
Pancreatic ductal adenocarcinoma is one of the deadliest carcinomas and is characterized by highly tumorigenic and metastatic cancer stem cells (CSC). CSCs evade available therapies, which preferentially target highly proliferative...
6.
Camacho-Vanegas O, Till J, Miranda-Lorenzo I, Ozturk B, Camacho S, Martignetti J
FASEB J
. 2012 Nov;
27(2):432-6.
PMID: 23134681
Alternative splicing represents a unique post-transcriptional mechanism that increases the complexity of the eukaryotic proteome-generating protein isoforms whose functions can be novel, diverse, and/or even antagonistic when compared to its...
7.
Camacho-Vanegas O, Camacho S, Till J, Miranda-Lorenzo I, Terzo E, Ramirez M, et al.
Am J Hum Genet
. 2012 Apr;
90(4):614-27.
PMID: 22464254
Diaphyseal medullary stenosis with malignant fibrous histiocytoma (DMS-MFH) is an autosomal-dominant syndrome characterized by bone dysplasia, myopathy, and bone cancer. We previously mapped the DMS-MFH tumor-suppressing-gene locus to chromosomal region...
8.
Lonardo E, Hermann P, Mueller M, Huber S, Balic A, Miranda-Lorenzo I, et al.
Cell Stem Cell
. 2011 Nov;
9(5):433-46.
PMID: 22056140
Nodal and Activin belong to the TGF-β superfamily and are important regulators of embryonic stem cell fate. Here we investigated whether Nodal and Activin regulate self-renewal of pancreatic cancer stem...
9.
Dorado J, Lonardo E, Miranda-Lorenzo I, Heeschen C
J Gastroenterol
. 2011 Jun;
46(8):966-73.
PMID: 21698355
Since the identification of self-renewing cells in the hematopoietic system several decades ago, stem cells have changed the way we study biology and medicine. Solid tumors contain a distinct subpopulation...