Ion C Cirstea
Overview
Explore the profile of Ion C Cirstea including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
444
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0
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Recent Articles
11.
Cirstea I, Gremer L, Dvorsky R, Zhang S, Piekorz R, Zenker M, et al.
Hum Mol Genet
. 2012 Oct;
22(2):262-70.
PMID: 23059812
Activating somatic and germline mutations of closely related RAS genes (H, K, N) have been found in various types of cancer and in patients with developmental disorders, respectively. The involvement...
12.
Jaiswal M, Gremer L, Dvorsky R, Haeusler L, Cirstea I, Uhlenbrock K, et al.
J Biol Chem
. 2011 Apr;
286(20):18202-12.
PMID: 21454492
The multimodular guanine nucleotide exchange factors (GEFs) of the Dbl family mostly share a tandem Dbl homology (DH) and pleckstrin homology (PH) domain organization. The function of these and other...
13.
Schmidt S, Essmann F, Cirstea I, Kuck F, Thakur H, Singh M, et al.
Cell Cycle
. 2010 Nov;
9(22):4469-73.
PMID: 21088502
Altered cell division is associated with overproliferation and tumorigenesis, however, mitotic aberrations can also trigger antiproliferative responses leading to postmitotic cell cycle exit. Here, we focus on the role of...
14.
Gremer L, Merbitz-Zahradnik T, Dvorsky R, Cirstea I, Kratz C, Zenker M, et al.
Hum Mutat
. 2010 Oct;
32(1):33-43.
PMID: 20949621
The KRAS gene is the most common locus for somatic gain-of-function mutations in human cancer. Germline KRAS mutations were shown recently to be associated with developmental disorders, including Noonan syndrome...
15.
Cirstea I, Kutsche K, Dvorsky R, Gremer L, Carta C, Horn D, et al.
Nat Genet
. 2009 Dec;
42(1):27-9.
PMID: 19966803
Noonan syndrome, a developmental disorder characterized by congenital heart defects, reduced growth, facial dysmorphism and variable cognitive deficits, is caused by constitutional dysregulation of the RAS-MAPK signaling pathway. Here we...