Ioannis Dragatsis
Overview
Explore the profile of Ioannis Dragatsis including associated specialties, affiliations and a list of published articles.
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46
Citations
2665
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Recent Articles
11.
Even A, Morelli G, Broix L, Scaramuzzino C, Turchetto S, Gladwyn-Ng I, et al.
Sci Adv
. 2020 Jan;
5(12):eaax2705.
PMID: 31897425
Microtubules are polymerized dimers of α- and β-tubulin that underlie a broad range of cellular activities. Acetylation of α-tubulin by the acetyltransferase ATAT1 modulates microtubule dynamics and functions in neurons....
12.
Morini E, Gao D, Montgomery C, Salani M, Mazzasette C, Krussig T, et al.
Am J Hum Genet
. 2019 Mar;
104(4):638-650.
PMID: 30905397
Familial dysautonomia (FD) is a recessive neurodegenerative disease caused by a splice mutation in Elongator complex protein 1 (ELP1, also known as IKBKAP); this mutation leads to variable skipping of...
13.
Shukla P, Meena A, Manda B, Gomes-Solecki M, Dietrich P, Dragatsis I, et al.
FASEB J
. 2018 Jun;
:fj201800351R.
PMID: 29912589
Pathogenesis of alcohol-related diseases such as alcoholic hepatitis involves gut barrier dysfunction, endotoxemia, and toxin-mediated cellular injury. Here we show that Lactobacillus plantarum not only blocks but also mitigates ethanol...
14.
Dietrich P, Johnson I, Alli S, Dragatsis I
PLoS Genet
. 2017 Jul;
13(7):e1006846.
PMID: 28715425
Huntington's Disease (HD) is an autosomal dominant progressive neurodegenerative disorder characterized by cognitive, behavioral and motor dysfunctions. HD is caused by a CAG repeat expansion in exon 1 of the...
15.
Xiao J, Vemula S, Xue Y, Khan M, Carlisle F, Waite A, et al.
Neurobiol Dis
. 2016 Nov;
98:52-65.
PMID: 27890709
Loss-of-function mutations in SGCE, which encodes ε-sarcoglycan (ε-SG), cause myoclonus-dystonia syndrome (OMIM159900, DYT11). A "major" ε-SG protein derived from CCDS5637.1 (NM_003919.2) and a "brain-specific" protein, that includes sequence derived from...
16.
Dietrich P, Dragatsis I
Genet Mol Biol
. 2016 Aug;
39(4):497-514.
PMID: 27561110
Hereditary Sensory and Autonomic Neuropathies (HSANs) compose a heterogeneous group of genetic disorders characterized by sensory and autonomic dysfunctions. Familial Dysautonomia (FD), also known as HSAN III, is an autosomal...
17.
Morini E, Dietrich P, Salani M, Downs H, Wojtkiewicz G, Alli S, et al.
Hum Mol Genet
. 2016 Jan;
25(6):1116-28.
PMID: 26769677
Familial dysautonomia (FD) is an autosomal recessive neurodegenerative disease that affects the development and survival of sensory and autonomic neurons. FD is caused by an mRNA splicing mutation in intron...
18.
Mir H, Meena A, Chaudhry K, Shukla P, Gangwar R, Manda B, et al.
Biochim Biophys Acta
. 2016 Jan;
1860(4):765-74.
PMID: 26721332
Background: Disruption of epithelial tight junctions (TJ), gut barrier dysfunction and endotoxemia play crucial role in the pathogenesis of alcoholic tissue injury. Occludin, a transmembrane protein of TJ, is depleted...
19.
Chaudhry K, Samak G, Shukla P, Mir H, Gangwar R, Manda B, et al.
Alcohol Clin Exp Res
. 2015 Jul;
39(8):1465-75.
PMID: 26173414
Background: Acetaldehyde, the toxic ethanol (EtOH) metabolite, disrupts intestinal epithelial barrier function. Aldehyde dehydrogenase (ALDH) detoxifies acetaldehyde into acetate. Subpopulations of Asians and Native Americans show polymorphism with loss-of-function mutations...
20.
McKinstry S, Karadeniz Y, Worthington A, Hayrapetyan V, Ozlu M, Serafin-Molina K, et al.
J Neurosci
. 2014 Jul;
34(28):9455-72.
PMID: 25009276
Huntington's disease (HD) is a neurodegenerative disease caused by the expansion of a poly-glutamine (poly-Q) stretch in the huntingtin (Htt) protein. Gain-of-function effects of mutant Htt have been extensively investigated...