Inmaculada Silos-Santiago
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Explore the profile of Inmaculada Silos-Santiago including associated specialties, affiliations and a list of published articles.
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28
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1182
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Recent Articles
1.
Jalanka J, Major G, Murray K, Singh G, Nowak A, Kurtz C, et al.
Int J Mol Sci
. 2019 Jan;
20(2).
PMID: 30669509
Psyllium is a widely used treatment for constipation. It traps water in the intestine increasing stool water, easing defaecation and altering the colonic environment. We aimed to assess the impact...
2.
Grundy L, Harrington A, Castro J, Garcia-Caraballo S, Deiteren A, Maddern J, et al.
JCI Insight
. 2018 Oct;
3(19).
PMID: 30282832
Irritable bowel syndrome (IBS) patients suffer from chronic abdominal pain and extraintestinal comorbidities, including overactive bladder (OAB) and interstitial cystitis/painful bladder syndrome (IC-PBS). Mechanistic understanding of the cause and time...
3.
Arora K, Huang Y, Mun K, Yarlagadda S, Sundaram N, Kessler M, et al.
JCI Insight
. 2017 Oct;
2(19).
PMID: 28978796
Cystic fibrosis (CF) is a genetic disorder in which epithelium-generated fluid flow from the lung, intestine, and pancreas is impaired due to mutations disrupting CF transmembrane conductance regulator (CFTR) channel...
4.
Ahsan M, Tchernychev B, Kessler M, Solinga R, Arthur D, Linde C, et al.
Physiol Rep
. 2017 Jun;
5(11).
PMID: 28592587
The transmembrane receptor guanylyl cyclase-C (GC-C), expressed on enterocytes along the intestine, is the molecular target of the GC-C agonist peptide linaclotide, an FDA-approved drug for treatment of adult patients...
5.
Tchernychev B, Ge P, Kessler M, Solinga R, Wachtel D, Tobin J, et al.
J Pharmacol Exp Ther
. 2015 Jul;
355(1):48-56.
PMID: 26216942
MRP4 mediates the efflux of cGMP and cAMP and acts as an important regulator of these secondary messengers, thereby affecting signaling events mediated by cGMP and cAMP. Immunofluorescence staining showed...
6.
Hannig G, Tchernychev B, Kurtz C, Bryant A, Currie M, Silos-Santiago I
Front Mol Neurosci
. 2014 May;
7:31.
PMID: 24795564
Activation of guanylate cyclase-C (GC-C) expressed predominantly on intestinal epithelial cells by guanylin, uroguanylin or the closely related GC-C agonist peptide, linaclotide, stimulates generation, and release of cyclic guanosine-3',5'-monophosphate (cGMP)....
7.
Castro J, Harrington A, Hughes P, Martin C, Ge P, Shea C, et al.
Gastroenterology
. 2013 Aug;
145(6):1334-46.e1-11.
PMID: 23958540
Background & Aims: Linaclotide is a minimally absorbed agonist of guanylate cyclase-C (GUCY2C or GC-C) that reduces symptoms associated with irritable bowel syndrome with constipation (IBS-C). Little is known about...
8.
Silos-Santiago I, Hannig G, Eutamene H, Ustinova E, Bernier S, Ge P, et al.
Pain
. 2013 Jun;
154(9):1820-1830.
PMID: 23748116
The natural hormone uroguanylin regulates intestinal fluid homeostasis and bowel function through activation of guanylate cyclase-C (GC-C), resulting in increased intracellular cyclic guanosine-3',5'-monophosphate (cGMP). We report the effects of uroguanylin-mediated...
9.
Feng B, Kiyatkin M, La J, Ge P, Solinga R, Silos-Santiago I, et al.
J Neurosci
. 2013 Jun;
33(23):9831-9.
PMID: 23739979
Irritable bowel syndrome (IBS) is characterized by altered bowel habits, persistent pain and discomfort, and typically colorectal hypersensitivity. Linaclotide, a peripherally restricted 14 aa peptide approved for the treatment of...
10.
Herradon G, Ezquerra L, Nguyen T, Wang C, Siso A, Franklin B, et al.
Neurosci Lett
. 2008 May;
438(2):186-9.
PMID: 18472331
The Fischer 344 (F344) rat strain differs from the Lewis strain in the response to neuropathic pain. Recently, we found that F344 rats totally recover from mechanical allodynia induced by...