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Inge Depoortere

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Articles 80
Citations 1766
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Recent Articles
1.
Leng H, Thijs T, Desmet L, Vanotti G, Farhadipour M, Depoortere I
Cell Mol Gastroenterol Hepatol . 2024 Dec; 19(4):101440. PMID: 39667578
Background & Aims: Circadian disturbances result in adverse health effects, including gastrointestinal symptoms. We investigated which physiological pathways in jejunal mucosa were disrupted during chronic jetlag and prevented during time-restricted...
2.
Wang Q, Farhadipour M, Thijs T, Ruilova Sosoranga E, Van der Schueren B, Ceulemans L, et al.
Mol Metab . 2024 Aug; 88:102002. PMID: 39111389
Objective: Growth differentiation factor 15 (GDF15), a stress related cytokine, was recently identified as a novel satiety signal acting via the GFRAL receptor located in the hindbrain. Bitter compounds are...
3.
Farhadipour M, Arnauts K, Clarysse M, Thijs T, Liszt K, Van der Schueren B, et al.
iScience . 2023 Dec; 26(12):108517. PMID: 38125020
Stem cells are a keystone of intestinal homeostasis, but their function could be shifted during energy imbalance or by crosstalk with microbial metabolites in the stem cell niche. This study...
4.
Ruilova Sosoranga E, Verbeure W, Geysen H, Thijs T, Matthys C, Depoortere I, et al.
Nutrients . 2023 Oct; 15(19). PMID: 37836548
The direct infusion of bitter solutions in the gastrointestinal tract can reduce the secretion of orexigenic hormones and influence appetite and food intake. We aimed to explore whether oral ingestion...
5.
Cheng W, Desmet L, Depoortere I
Acta Physiol (Oxf) . 2023 Aug; 239(2):e14027. PMID: 37553828
The circadian timing system enables organisms to adapt their physiology and behavior to the cyclic environmental changes including light-dark cycle or food availability. Misalignment between the endogenous circadian rhythms and...
6.
Bijnens S, Depoortere I
Physiol Behav . 2023 Feb; 263:114103. PMID: 36731762
The mammalian circadian clocks are entrained by environmental time cues, such as the light-dark cycle and the feeding-fasting cycle. In modern society, circadian misalignment is increasingly more common under the...
7.
Desmet L, Thijs T, Segers A, Depoortere I
Neurogastroenterol Motil . 2022 Oct; 35(1):e14487. PMID: 36264144
Background: Secondary bile acids entrain peripheral circadian clocks and inhibit colonic motility via the bile acid receptor GPBAR1. We aimed to investigate whether chronodisruption affected the rhythm in serum bile...
8.
9.
Desmet L, Thijs T, Mas R, Verbeke K, Depoortere I
Nutrients . 2021 Nov; 13(11). PMID: 34836101
We used time-restricted feeding (TRF) to investigate whether microbial metabolites and the hunger hormone ghrelin can become the dominant entraining factor during chronic jetlag to prevent disruption of the master...
10.
Liszt K, Wang Q, Farhadipour M, Segers A, Thijs T, Nys L, et al.
J Clin Invest . 2021 Nov; 132(3). PMID: 34784295
Bitter taste receptors (taste 2 receptors, TAS2Rs) serve as warning sensors in the lingual system against the ingestion of potentially poisonous food. Here, we investigated the functional role of TAS2Rs...