Ines Sequeira
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Explore the profile of Ines Sequeira including associated specialties, affiliations and a list of published articles.
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24
Citations
477
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Recent Articles
11.
Sequeira I, Rashid M, Tomas I, Williams M, Graham T, Adams D, et al.
Nat Commun
. 2020 Nov;
11(1):5671.
PMID: 33168804
To establish whether 4-nitroquinoline N-oxide-induced carcinogenesis mirrors the heterogeneity of human oral squamous cell carcinoma (OSCC), we have performed genomic analysis of mouse tongue lesions. The mutational signatures of human...
12.
Joost S, Annusver K, Jacob T, Sun X, Dalessandri T, Sivan U, et al.
Cell Stem Cell
. 2020 Feb;
26(3):441-457.e7.
PMID: 32109378
Skin homeostasis is orchestrated by dozens of cell types that together direct stem cell renewal, lineage commitment, and differentiation. Here, we use single-cell RNA sequencing and single-molecule RNA FISH to...
13.
Byrd K, Piehl N, Patel J, Huh W, Sequeira I, Lough K, et al.
Cell Stem Cell
. 2019 Dec;
25(6):814-829.e6.
PMID: 31809739
Stem cells in stratified epithelia are generally believed to adhere to a non-hierarchical single-progenitor model. Using lineage tracing and genetic label-retention assays, we show that the hard palatal epithelium of...
14.
Sequeira I, Watt F
Cell Stress
. 2019 Jun;
3(4):136-138.
PMID: 31225508
Keratins are intermediate filament proteins expressed by epithelial cells and provide mechanical support for diverse epithelia. In our recent study (Sequeira Nat Comm 9(1):3437), we analysed the role of keratin...
15.
Sequeira I, Neves J, Carrero D, Peng Q, Palasz N, Liakath-Ali K, et al.
Nat Commun
. 2018 Aug;
9(1):3437.
PMID: 30143634
Keratin 76 (Krt76) is expressed in the differentiated epithelial layers of skin, oral cavity and squamous stomach. Krt76 downregulation in human oral squamous cell carcinomas (OSCC) correlates with poor prognosis....
16.
Liakath-Ali K, Mills E, Sequeira I, Lichtenberger B, Pisco A, Sipila K, et al.
Nature
. 2018 Apr;
556(7701):376-380.
PMID: 29643507
Ribosome-associated mRNA quality control mechanisms ensure the fidelity of protein translation. Although these mechanisms have been extensively studied in yeast, little is known about their role in mammalian tissues, despite...
17.
Liakath-Ali K, Vancollie V, Sequeira I, Lelliott C, Watt F
Exp Dermatol
. 2018 Mar;
28(4):391-394.
PMID: 29509981
Myosins are molecular motors that are well known for their role in cell movement and contractile functions. Although extensively studied in muscle physiology, little is known about the function of...
18.
Telerman S, Rognoni E, Sequeira I, Pisco A, Lichtenberger B, Culley O, et al.
J Invest Dermatol
. 2017 Jul;
137(11):2270-2281.
PMID: 28668474
B-lymphocyte-induced maturation protein 1 (Blimp1) is a transcriptional repressor that regulates cell growth and differentiation in multiple tissues, including skin. Although in the epidermis Blimp1 is important for keratinocyte and...
19.
Weber C, Telerman S, Reimer A, Sequeira I, Liakath-Ali K, Arwert E, et al.
Cancer Res
. 2016 Jan;
76(4):805-817.
PMID: 26754935
Macrophages are essential for the progression and maintenance of many cancers, but their role during the earliest stages of tumor formation is unclear. To test this, we used a previously...
20.
Sequeira I, Legue E, Capgras S, Nicolas J
Methods Mol Biol
. 2013 Nov;
1195:247-58.
PMID: 24281870
In vivo lineage tracing is a valuable technique to study cellular behavior. Our lab developed a lineage tracing method, based on the Cre/lox system, to genetically induce clonal labelling of...