Indra Schroeder
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Explore the profile of Indra Schroeder including associated specialties, affiliations and a list of published articles.
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30
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323
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Recent Articles
1.
Korn T, Hansen U, Gabriel T, Rauh O, Drexler N, Schroeder I
Channels (Austin)
. 2024 Oct;
18(1):2402749.
PMID: 39383513
Kcv channels from plant viruses represent the autonomous pore module of potassium channels, devoid of any regulatory domains. These small proteins show very reproducible single-channel behavior in planar lipid bilayers....
2.
Rauh O, Opper J, Sturm M, Drexler N, Scheub D, Hansen U, et al.
J Mol Biol
. 2022 Mar;
434(9):167522.
PMID: 35248543
Most potassium channels have two main gate locations, hosting an inner gate at the cytosolic entrance and a filter gate in the selectivity filter; the function of these gates is...
3.
Gabriel T, Hansen U, Urban M, Drexler N, Winterstein T, Rauh O, et al.
Front Physiol
. 2021 Nov;
12:737834.
PMID: 34777005
Modulating the activity of ion channels by blockers yields information on both the mode of drug action and on the biophysics of ion transport. Here we investigate the interplay between...
4.
Schmidt M, Schroeder I, Bauer D, Thiel G, Hamacher K
Eur Biophys J
. 2021 Feb;
50(1):37-57.
PMID: 33523249
Coarse-grained protein models approximate the first-principle physical potentials. Among those modeling approaches, the relative entropy framework yields promising and physically sound results, in which a mapping from the target protein...
5.
Distinct lipid bilayer compositions have general and protein-specific effects on K+ channel function
Winterstein L, Kukovetz K, Hansen U, Schroeder I, Van Etten J, Moroni A, et al.
J Gen Physiol
. 2021 Jan;
153(2).
PMID: 33439243
It has become increasingly apparent that the lipid composition of cell membranes affects the function of transmembrane proteins such as ion channels. Here, we leverage the structural and functional diversity...
6.
Eckert D, Schulze T, Stahl J, Rauh O, Van Etten J, Hertel B, et al.
Channels (Austin)
. 2019 Apr;
13(1):124-135.
PMID: 31010373
Some algal viruses have coding sequences for proteins with structural and functional characteristics of pore modules of complex K channels. Here we exploit the structural diversity among these channel orthologs...
7.
Hartel A, Shekar S, Ong P, Schroeder I, Thiel G, Shepard K
Anal Chim Acta
. 2019 Mar;
1061:13-27.
PMID: 30926031
Transport processes through ion-channel proteins, protein pores, or solid-state nanopores are traditionally recorded with commercial patch-clamp amplifiers. The bandwidth of these systems is typically limited to 10 kHz by signal-to-noise-ratio...
8.
Winterstein L, Kukovetz K, Rauh O, Turman D, Braun C, Moroni A, et al.
J Gen Physiol
. 2018 Mar;
150(4):637-646.
PMID: 29487088
Recent studies have shown that membrane proteins can be efficiently synthesized in vitro before spontaneously inserting into soluble nanoscale lipid bilayers called nanodiscs (NDs). In this paper, we present experimental...
9.
Hartel A, Ong P, Schroeder I, Giese M, Shekar S, Clarke O, et al.
Proc Natl Acad Sci U S A
. 2018 Feb;
115(8):E1789-E1798.
PMID: 29432144
Single-channel recordings are widely used to explore functional properties of ion channels. Typically, such recordings are performed at bandwidths of less than 10 kHz because of signal-to-noise considerations, limiting the...
10.
Rauh O, Hansen U, Mach S, Hartel A, Shepard K, Thiel G, et al.
FEBS Lett
. 2017 Nov;
591(23):3850-3860.
PMID: 29106736
Lipid bilayers provide many benefits for ion channel recordings, such as control of membrane composition and transport molecules. However, they suffer from high membrane capacitance limiting the bandwidth and impeding...