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Imelda Winarsih

Explore the profile of Imelda Winarsih including associated specialties, affiliations and a list of published articles. Areas
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Articles 4
Citations 46
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Recent Articles
1.
Subramanian K, Winarsih I, Keerthani C, Ho B, Ding J
J Innate Immun . 2014 Apr; 6(4):515-29. PMID: 24685988
Hemolysis releases hemoglobin (Hb), a prooxidant, into circulation. While the heme iron is a nutrient for the invading pathogens, it releases ROS, which is both microbicidal and cytotoxic, making it...
2.
Bahl N, Winarsih I, Tucker-Kellogg L, Ding J
Thromb Haemost . 2013 Oct; 111(1):67-78. PMID: 24108579
The mechanisms of crosstalk between haemolysis, coagulation and innate immunity are evolutionarily conserved from the invertebrate haemocyanin to the vertebrate haemoglobin (Hb). In vertebrates, extracellular Hb resulting from haemolytic infections...
3.
Du R, Winarsih I, Ho B, Ding J
Am J Clin Exp Immunol . 2013 Jul; 1(1):33-48. PMID: 23885313
Cell-free hemoglobin (Hb) resulting from hemolysis is redox-active. It disrupts the oxidoreducing microenvironment, shifting the balance unfavorably towards tissue cytotoxicity. Thus, immediate suppression of the Hb-redox activity and removal of...
4.
Bahl N, Du R, Winarsih I, Ho B, Tucker-Kellogg L, Tidor B, et al.
J Biol Chem . 2011 Sep; 286(43):37793-803. PMID: 21900232
Hemoglobin (Hb) functions as a frontline defense molecule during infection by hemolytic microbes. Binding to LPS induces structural changes in cell-free Hb, which activates the redox activity of the protein...