Ilya Shmulevich
Overview
Explore the profile of Ilya Shmulevich including associated specialties, affiliations and a list of published articles.
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147
Citations
18891
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Recent Articles
11.
Echlin M, Aguilar B, Shmulevich I
Entropy (Basel)
. 2023 Feb;
25(2).
PMID: 36832685
Communication between cells enables the coordination that drives structural and functional complexity in biological systems. Both single and multicellular organisms have evolved diverse communication systems for a range of purposes,...
12.
Tercan B, Qin G, Kim T, Aguilar B, Phan J, Longabaugh W, et al.
F1000Res
. 2023 Feb;
11:493.
PMID: 36761837
Synthetic lethal interactions (SLIs), genetic interactions in which the simultaneous inactivation of two genes leads to a lethal phenotype, are promising targets for therapeutic intervention in cancer, as exemplified by...
13.
Stahlberg E, Abdel-Rahman M, Aguilar B, Asadpoure A, Beckman R, Borkon L, et al.
Front Digit Health
. 2022 Oct;
4:1007784.
PMID: 36274654
We are rapidly approaching a future in which cancer patient digital twins will reach their potential to predict cancer prevention, diagnosis, and treatment in individual patients. This will be realized...
14.
Tercan B, Aguilar B, Huang S, Dougherty E, Shmulevich I
iScience
. 2022 Sep;
25(9):104951.
PMID: 36093045
We developed a computational approach to find the best intervention to achieve transcription factor (TF) mediated transdifferentiation. We construct probabilistic Boolean networks (PBNs) from single-cell RNA sequencing data of two...
15.
Silverstein A, Dudaev A, Studneva M, Aitken J, Blokh S, Miller A, et al.
Prog Mol Biol Transl Sci
. 2022 Aug;
190(1):219-276.
PMID: 36008000
Medical abzymology has made a great contribution to the development of general autoimmunity theory: it has put the autoantibodies (Ab) as the key brick of the theory to the level...
16.
Moser R, Gurley K, Nikolova O, Qin G, Joshi R, Mendez E, et al.
Oncogene
. 2022 May;
41(24):3355-3369.
PMID: 35538224
The oncogene Ras and the tumor suppressor gene p53 are frequently co-mutated in human cancer and mutations in Ras and p53 can cooperate to generate a more malignant cell state....
17.
Qin G, Knijnenburg T, Gibbs D, Moser R, Monnat Jr R, Kemp C, et al.
Cell Rep
. 2022 Jan;
38(3):110269.
PMID: 35045296
Cells are complex systems in which many functions are performed by different genetically defined and encoded functional modules. To systematically understand how these modules respond to drug or genetic perturbations,...
18.
Hernandez-Boussard T, Macklin P, Greenspan E, Gryshuk A, Stahlberg E, Syeda-Mahmood T, et al.
Nat Med
. 2021 Nov;
27(12):2065-2066.
PMID: 34824458
No abstract available.
19.
Gibbs D, Aguilar B, Thorsson V, Ratushny A, Shmulevich I
Front Genet
. 2021 Sep;
12:667382.
PMID: 34512714
The maintenance and function of tissues in health and disease depends on cell-cell communication. This work shows how high-level features, representing cell-cell communication, can be defined and used to associate...
20.
Fedorov A, R Longabaugh W, Pot D, Clunie D, Pieper S, Aerts H, et al.
Cancer Res
. 2021 Jun;
81(16):4188-4193.
PMID: 34185678
The National Cancer Institute (NCI) Cancer Research Data Commons (CRDC) aims to establish a national cloud-based data science infrastructure. Imaging Data Commons (IDC) is a new component of CRDC supported...