Ilmo E Hassinen
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Explore the profile of Ilmo E Hassinen including associated specialties, affiliations and a list of published articles.
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30
Citations
840
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Recent Articles
1.
Kiiskila J, Hassinen I, Kettunen J, Kytovuori L, Mikkola I, Harkonen P, et al.
BMC Sports Sci Med Rehabil
. 2022 May;
14(1):95.
PMID: 35619160
Background: Endurance exercise training promotes the catabolism of branched-chain amino acids (BCAAs) in skeletal muscles. We have previously shown that mitochondrial DNA (mtDNA) haplogroups J and K are markers of...
2.
Hassinen I
Antioxid Redox Signal
. 2017 Dec;
30(6):857-874.
PMID: 29284289
Significance: NAD and NADP are important cosubstrates in redox reactions and participate in regulatory networks operating in adjustment of metabolic pathways. Moreover, NAD is a cosubstrate in post-translational modification of...
3.
Hautakangas M, Hinttala R, Rantala H, Nieminen P, Uusimaa J, Hassinen I
Mitochondrion
. 2016 May;
29:53-8.
PMID: 27223842
Due to the relative rarity of mitochondrial diseases, generating reference ranges is problematic in evaluation of respiratory chain activities particularly in pediatric cases. We determined the sample distribution of respiratory...
4.
Lindroos M, Parkka J, Taittonen M, Iozzo P, Karppa M, Hassinen I, et al.
J Inherit Metab Dis
. 2015 Jun;
39(1):67-74.
PMID: 26112752
Mitochondrial mutations impair glucose oxidation and increase glucose uptake in cell cultures and lead to cardiomyopathy in patients. Here we characterize cardiac glucose uptake in 14 patients with the m.3243A ...
5.
Patsi J, Kervinen M, Kytovuori L, Majamaa K, Hassinen I
Mitochondrion
. 2015 Mar;
22:23-30.
PMID: 25747201
Effects of Complex I mutations were studied by modeling in NuoH, NuoJ or NuoK subunits of Escherichia coli NDH-1 by simultaneous optical monitoring of deamino-NADH oxidation and proton translocation and...
6.
Napankangas J, Liimatta E, Joensuu P, Bergmann U, Ylitalo K, Hassinen I
J Mol Cell Cardiol
. 2012 Oct;
53(6):906-15.
PMID: 23036824
Reactive oxygen species (ROS) have been implicated in many aspects of tissue/cellular metabolic signaling and pathology, including cardioprotection against ischemia-reperfusion damage. Recent reports of enhanced ROS production under global or...
7.
Patsi J, Maliniemi P, Pakanen S, Hinttala R, Uusimaa J, Majamaa K, et al.
Biochim Biophys Acta
. 2011 Nov;
1817(2):312-8.
PMID: 22079202
Defects in complex I due to mutations in mitochondrial DNA are associated with clinical features ranging from single organ manifestation like Leber hereditary optic neuropathy (LHON) to multiorgan disorders like...
8.
Hinttala R, Kervinen M, Uusimaa J, Maliniemi P, Finnila S, Rantala H, et al.
Mitochondrion
. 2010 Mar;
10(4):358-61.
PMID: 20197120
MtDNA sequence variation is presumed to be neutral in effect, but associations with diseases and mtDNA haplogroups have been reported. The aim here was to evaluate the functional consequences of...
9.
Hyvarinen J, Hassinen I, Sormunen R, Maki J, Kivirikko K, Koivunen P, et al.
J Biol Chem
. 2010 Feb;
285(18):13646-57.
PMID: 20185832
Hypoxia-inducible factor (HIF) has a pivotal role in oxygen homeostasis and cardioprotection mediated by ischemic preconditioning. Its stability is regulated by HIF prolyl 4-hydroxylases (HIF-P4Hs), the inhibition of which is...
10.
Pietila M, Lehtonen S, Narhi M, Hassinen I, Leskela H, Aranko K, et al.
Tissue Eng Part C Methods
. 2009 Oct;
16(3):435-45.
PMID: 19839730
Advanced therapies medicinal products (ATMPs) have introduced innovative cell-based products. However, the regulatory demands for characterization of ATMPs are currently unable to adequately address the safety of such products. As...