Iliyana Stefanova
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Explore the profile of Iliyana Stefanova including associated specialties, affiliations and a list of published articles.
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10
Citations
39
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Recent Articles
1.
Stoyanova M, Milusheva M, Gledacheva V, Stefanova I, Todorova M, Kircheva N, et al.
Biomedicines
. 2024 Oct;
12(10).
PMID: 39457637
: Irritable bowel syndrome (IBS) has a major negative influence on quality of life, causing cramps, stomach pain, bloating, constipation, etc. Antispasmodics have varying degrees of efficacy. Mebeverine, for example,...
2.
Slavchev V, Gledacheva V, Pencheva M, Milusheva M, Nikolova S, Stefanova I
Molecules
. 2024 Aug;
29(16).
PMID: 39202883
The synthesized compound 1-(2-chlorophenyl) 6-7-dimethoxy-3-methyl-3,4-dihydroisoquinoline (DIQ) was investigated as a biological agent. Its potential to affect muscle contractility was predicted through in silico PASS analysis. Based on the in silico...
3.
Milusheva M, Stoyanova M, Gledacheva V, Stefanova I, Todorova M, Pencheva M, et al.
Molecules
. 2024 Jul;
29(14).
PMID: 39064953
Irritable bowel syndrome (IBS) is a common gastrointestinal (GI) disorder characterized by abdominal pain or discomfort. Mebeverine is an antispasmodic that has been widely used in clinical practice to relieve...
4.
Milusheva M, Stoyanova M, Gledacheva V, Stefanova I, Todorova M, Nikolova S
Biomedicines
. 2024 Jul;
12(7).
PMID: 39062129
This article concerns the spasmolytic activities of some novel 1,3-disubstituted 3,4-dihydroisoquinolines. These compounds can be evaluated as potential therapeutic candidates according to Lipinski's rule of five, showing high gastrointestinal absorption...
5.
Milusheva M, Todorova M, Gledacheva V, Stefanova I, Feizi-Dehnayebi M, Pencheva M, et al.
Pharmaceuticals (Basel)
. 2023 Dec;
16(12).
PMID: 38139787
Anti-inflammatory drugs are used to relieve pain, fever, and inflammation while protecting the cardiovascular system. However, the side effects of currently available medications have limited their usage. Due to these...
6.
Milusheva M, Gledacheva V, Stefanova I, Feizi-Dehnayebi M, Mihaylova R, Nedialkov P, et al.
Int J Mol Sci
. 2023 Sep;
24(18).
PMID: 37762158
The present article focuses on the synthesis and biological evaluation of a novel anthranilic acid hybrid and its diamides as antispasmodics. Methods: Due to the predicted in silico methods spasmolytic...
7.
Nikolova S, Milusheva M, Gledacheva V, Feizi-Dehnayebi M, Kaynarova L, Georgieva D, et al.
Biomedicines
. 2023 Aug;
11(8).
PMID: 37626698
Anticoagulants prevent the blood from developing the coagulation process, which is the primary cause of death in thromboembolic illnesses. Phenindione (PID) is a well-known anticoagulant that is rarely employed because...
8.
Milusheva M, Gledacheva V, Stefanova I, Pencheva M, Mihaylova R, Tumbarski Y, et al.
Biomedicines
. 2023 Feb;
11(2).
PMID: 36831141
Methods: In silico analysis aimed at predicting the pharmacodynamic profile of the compounds was performed. Based on these predictions, ex vivo bioelectrical activity (BEA) and immunohistochemical effects of the compounds...
9.
Brazkova M, Angelova G, Mihaylova D, Stefanova P, Pencheva M, Gledacheva V, et al.
Foods
. 2022 Dec;
11(24).
PMID: 36553726
Higher basidiomycetes are recognized as functional foods due to their bioactive compound content, which exerts various beneficial effects on human health, and which have been used as sources for the...
10.
Ivanov I, Nikolova S, Aladjov D, Stefanova I, Zagorchev P
Molecules
. 2011 Aug;
16(8):7019-42.
PMID: 21847072
A series of different 1-monosubstituted and 1,1-disubstituted 1,2,3,4-tetrahydro-isoquinolines was synthesized in high yields from different ketoamides. We have developed a convenient method for the synthesis of disubstituted derivatives by interaction...