Ilaria Ottonelli
Overview
Explore the profile of Ilaria Ottonelli including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
228
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Recent Articles
11.
Ottonelli I, Duskey J, Genovese F, Pederzoli F, Caraffi R, Valenza M, et al.
Int J Pharm X
. 2022 Oct;
4:100136.
PMID: 36304137
Nanoparticles (NPs) are paving the way for improved treatments for difficult to treat diseases diseases; however, much is unknown about their fate in the body. One important factor is the...
12.
Djoudi A, Molina-Pena R, Ferreira N, Ottonelli I, Tosi G, Garcion E, et al.
Int J Mol Sci
. 2022 Oct;
23(20).
PMID: 36293030
Hyaluronic acid (HA) is a Glycosaminoglycan made of disaccharide units containing N-acetyl-D-glucosamine and glucuronic acid. Its molecular mass can reach 10 MDa and its physiological properties depend on its polymeric...
13.
Duskey J, Rinaldi A, Ottonelli I, Caraffi R, De Benedictis C, Sauer A, et al.
Pharmaceutics
. 2022 Jul;
14(7).
PMID: 35890345
Glioblastoma Multiforme (GBM) is a devastating disease with a low survival rate and few efficacious treatment options. The fast growth, late diagnostics, and off-target toxicity of currently used drugs represent...
14.
Ottonelli I, Caraffi R, Tosi G, Vandelli M, Duskey J, Ruozi B
Int J Mol Sci
. 2022 Feb;
23(4).
PMID: 35216348
Tunneling nanotubes (TNTs), discovered in 2004, are thin, long protrusions between cells utilized for intercellular transfer and communication. These newly discovered structures have been demonstrated to play a crucial role...
15.
Duskey J, Ottonelli I, Rinaldi A, Parmeggiani I, Zambelli B, Wang L, et al.
Nanomaterials (Basel)
. 2021 Nov;
11(11).
PMID: 34835710
Enzymes, as natural and potentially long-term treatment options, have become one of the most sought-after pharmaceutical molecules to be delivered with nanoparticles (NPs); however, their instability during formulation often leads...
16.
Ottonelli I, Duskey J, Rinaldi A, Grazioli M, Parmeggiani I, Vandelli M, et al.
Pharmaceutics
. 2021 Sep;
13(9).
PMID: 34575571
Microfluidic technologies have recently been applied as innovative methods for the production of a variety of nanomedicines (NMeds), demonstrating their potential on a global scale. The capacity to precisely control...
17.
Birolini G, Valenza M, Ottonelli I, Passoni A, Favagrossa M, Duskey J, et al.
J Control Release
. 2021 Jan;
330:587-598.
PMID: 33412229
Supplementing brain cholesterol is emerging as a potential treatment for Huntington's disease (HD), a genetic neurodegenerative disorder characterized, among other abnormalities, by inefficient brain cholesterol biosynthesis. However, delivering cholesterol to...
18.
Duskey J, da Ros F, Ottonelli I, Zambelli B, Vandelli M, Tosi G, et al.
Molecules
. 2020 Oct;
25(20).
PMID: 33050145
Enzymes have gained attention for their role in numerous disease states, calling for research for their efficient delivery. Loading enzymes into polymeric nanoparticles to improve biodistribution, stability, and targeting in...
19.
Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles
Lutz A, Pfaender S, Incearap B, Ioannidis V, Ottonelli I, Fohr K, et al.
Sci Transl Med
. 2020 Jun;
12(547).
PMID: 32522805
Heterozygous mutations of the gene encoding the postsynaptic protein SHANK3 are associated with syndromic forms of autism spectrum disorders (ASDs). One of the earliest clinical symptoms in SHANK3-associated ASD is...
20.
Duskey J, Ottonelli I, da Ros F, Vilella A, Zoli M, Kovachka S, et al.
Nanomedicine
. 2020 Jun;
28:102226.
PMID: 32479916
Central nervous system (CNS) compartments remain one of the most difficult districts for drug delivery. This is due to the presence of the blood-brain barrier (BBB) that hampers 90% of...