Ikwunga Wonodi
Overview
Explore the profile of Ikwunga Wonodi including associated specialties, affiliations and a list of published articles.
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Articles
30
Citations
791
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Recent Articles
1.
Kelly D, Glassman M, Wonodi I, Vyas G, Richardson C, Nwulia E, et al.
Schizophr Res
. 2023 Aug;
268():312-322.
PMID: 37633776
Introduction: Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia, but it is markedly underutilized, particularly in the US Black population, partly because of concern over clozapine-associated low absolute neutrophil...
2.
Patchan K, Vyas G, Hackman A, Mackowick M, Richardson C, Love R, et al.
Psychiatr Q
. 2017 Jun;
89(1):157-168.
PMID: 28643049
Popular media often portray people with a mental illness as being aggressive, violent, and incarcerated as a result of their behavior. Despite exaggeration in the media, risks for some aggressive...
3.
Wonodi I, McMahon R, Krishna N, Mitchell B, Liu J, Glassman M, et al.
Schizophr Res
. 2014 Dec;
160(1-3):80-7.
PMID: 25464917
Background: Cognitive deficits compromise quality of life and productivity for individuals with schizophrenia and have no effective treatments. Preclinical data point to the kynurenine pathway of tryptophan metabolism as a...
4.
Hong L, Thaker G, McMahon R, Summerfelt A, RachBeisel J, Fuller R, et al.
Arch Gen Psychiatry
. 2011 Aug;
68(12):1195-206.
PMID: 21810630
Context: The administration of nicotine transiently improves many neurobiological and cognitive functions in schizophrenia and schizoaffective disorder. It is not yet clear which nicotinic acetylcholine receptor (nAChR) subtype or subtypes...
5.
Wonodi I, Stine O, Sathyasaikumar K, Roberts R, Mitchell B, Hong L, et al.
Arch Gen Psychiatry
. 2011 Jul;
68(7):665-74.
PMID: 21727251
Context: Kynurenic acid, a metabolite of the kynurenine pathway of tryptophan degradation, is an antagonist at N-methyl-d-aspartate and α7 nicotinic acetylcholine receptors and modulates glutamate, dopamine, and acetylcholine signaling. Cortical...
6.
Wonodi I, Gopinath H, Liu J, Adami H, Hong L, Allen-Emerson R, et al.
Psychopharmacology (Berl)
. 2011 May;
218(2):341-5.
PMID: 21537940
Background: Emerging data indicate the neuromodulator adenosine may play a role in the therapeutics of schizophrenia. Adenosine A(2A) receptor stimulation exerts a functional antagonism at postsynaptic D(2) receptors. Data from...
7.
Sathyasaikumar K, Stachowski E, Wonodi I, Roberts R, Rassoulpour A, McMahon R, et al.
Schizophr Bull
. 2010 Nov;
37(6):1147-56.
PMID: 21036897
The levels of kynurenic acid (KYNA), an astrocyte-derived metabolite of the branched kynurenine pathway (KP) of tryptophan degradation and antagonist of α7 nicotinic acetylcholine and N-methyl-D-aspartate receptors, are elevated in...
8.
Weiner E, Conley R, Ball M, Feldman S, Gold J, Kelly D, et al.
Neuropsychopharmacology
. 2010 Jul;
35(11):2274-83.
PMID: 20664583
The large numbers of partial clozapine responders represent a major therapeutic challenge. Unfortunately, there are no clear data to support how best to treat these patients. This study examines the...
9.
Wonodi I, Schwarcz R
Schizophr Bull
. 2010 Feb;
36(2):211-8.
PMID: 20147364
The brain concentration of kynurenic acid (KYNA), a metabolite of the kynurenine pathway of tryptophan degradation and antagonist at both the glycine coagonist site of the N-methyl-D-aspartic acid receptor (NMDAR)...
10.
Hong L, Schroeder M, Ross T, Buchholz B, Salmeron B, Wonodi I, et al.
Schizophr Bull
. 2009 Aug;
37(2):416-25.
PMID: 19713300
Sustained attention abnormality in schizophrenia is usually refractory to available treatment. Nicotine can transiently improve sustained attention in schizophrenia patients, although its neural mechanisms are unknown. Understanding the neural basis...