Ikuo Tooyama
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Explore the profile of Ikuo Tooyama including associated specialties, affiliations and a list of published articles.
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Articles
173
Citations
2061
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Recent Articles
1.
Wan Ngah W, Ahmad H, Ankasha S, Makpol S, Tooyama I
Antioxidants (Basel)
. 2025 Jan;
13(12.
PMID: 39765832
Alzheimer's disease (AD), which is characterized by deterioration in cognitive function and neuronal death, is the most prevalent age-related progressive neurodegenerative disease. Clinical and experimental research has revealed that gut...
2.
Ramli N, Yahaya M, Fahami N, Hamezah H, Bakar Z, Arrozi A, et al.
Exp Gerontol
. 2024 Nov;
198:112627.
PMID: 39487063
No abstract available.
3.
Tsubaki H, Mendsaikhan A, Buyandelger U, Tooyama I, Walker D
NeuroSci
. 2024 Nov;
3(2):166-185.
PMID: 39483368
Thioredoxin-Interacting Protein (TXNIP) has been shown to have significant pathogenic roles in many human diseases, particularly those associated with diabetes and hyperglycemia. Its main mode of action is to sequester...
4.
Ramli N, Yahaya M, Fahami N, Hamezah H, Bakar Z, Arrozi A, et al.
Exp Gerontol
. 2024 Oct;
197:112607.
PMID: 39389279
The menopausal transition is a complex neuroendocrine aging process affecting brain structure and metabolic function. Such changes are consistent with neurological sequelae noted following the menopausal transition, including cognitive deficits....
5.
Takahata S, Kato T, Yanagisawa D, Tsubaki H, Bakar Z, Mukaisho K, et al.
Acta Histochem Cytochem
. 2024 Jul;
57(3):101-108.
PMID: 38988693
Mitochondrial ferritin (FtMt) is a novel ferritin that sequesters iron and plays a protective role against oxidative stress. FtMt shares a high homology with H-ferritin but is expressed only in...
6.
Hashim K, Matsuba Y, Takahashi M, Kamano N, Tooyama I, Saido T, et al.
FEBS Lett
. 2024 May;
598(13):1576-1590.
PMID: 38789405
Alzheimer's disease (AD) involves reduced glutathione levels, causing oxidative stress and contributing to neuronal cell death. Our prior research identified diminished glutamate-cysteine ligase catalytic subunit (GCLC) as linked to cell...
7.
Shibukawa T, Fujiyoshi A, Moniruzzaman M, Miyagawa N, Kadota A, Kondo K, et al.
Prev Med Rep
. 2024 Feb;
38:102615.
PMID: 38375168
Background: Increasing physical activity may prevent cognitive decline. Previous studies primarily focused on older adults and used self-reported questionnaires to assess physical activity. We examined the relationship between step count,...
8.
Tooyama I, Kato T, Taguchi H, Kageyama Y, Irie K, Hirahara Y, et al.
Acta Histochem Cytochem
. 2024 Feb;
56(6):87-94.
PMID: 38318103
In the pathogenesis of Alzheimer's disease (AD), highly neurotoxic amyloid-β (Aβ) oligomers appear early, they are thus considered to be deeply involved in the onset of Alzheimer's disease. However, Aβ...
9.
Aldoghachi A, Yanagisawa D, Arrozi A, Bakar Z, Taguchi H, Ishigaki S, et al.
Biochem Biophys Res Commun
. 2023 Dec;
694:149392.
PMID: 38142581
Thioredoxin interacting protein (TXNIP) has emerged as a significant regulator of β-cell mass and loss, rendering it an attractive target for treating diabetes. We previously showed that Shiga-Y6, a fluorinated...
10.
Azahar N, Yano Y, Kadota A, Shiino A, Syaifullah A, Miyagawa N, et al.
J Am Heart Assoc
. 2023 May;
12(11):e028586.
PMID: 37232267
Background Little is known regarding whether arterial stiffness and atherosclerotic burden are each independently associated with brain structural changes. Simultaneous assessments of both arterial stiffness and atherosclerotic burden in associations...