Ikuo Tooyama
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Explore the profile of Ikuo Tooyama including associated specialties, affiliations and a list of published articles.
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173
Citations
2061
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Recent Articles
11.
Nishie T, Ohta Y, Shirai E, Higaki S, Shimozawa N, Narita K, et al.
Genes Cells
. 2023 May;
28(7):516-525.
PMID: 37186436
Tektins are a group of microtubule-stabilizing proteins necessary for cilia and flagella assembly. TEKTIN1 (TEKT1) is used as a sperm marker for monitoring germ cell differentiation in embryonic stem (ES)...
12.
Tsubaki H, Yanagisawa D, Kageyama Y, Hafiz Abu Baker Z, Mukaisho K, Tooyama I
Acta Histochem Cytochem
. 2023 May;
56(2):21-27.
PMID: 37124956
Mitochondrial ferritin (FtMt) is an endogenous iron-storage protein localized in the mitochondria. FtMt is mainly observed in restricted tissues, such as those in the testis, islets of Langerhans, and brain....
13.
Nishie T, Komaru A, Shiroguchi S, Yamaizumi T, Ono Y, Motomochi A, et al.
Toxicol In Vitro
. 2023 Feb;
89:105565.
PMID: 36746343
Nonylphenol (NP), an endocrine disrupting chemical, is widely used in industrial and agricultural processes, causing NP influx into aquatic environments. NP induces hormonal imbalance, and male feminization, and reduces germ...
14.
Azlan U, Annuar N, Mediani A, Aizat W, Damanhuri H, Tong X, et al.
Front Pharmacol
. 2023 Jan;
13:1035220.
PMID: 36686668
Neurodegenerative diseases (NDs) are sporadic maladies that affect patients' lives with progressive neurological disabilities and reduced quality of life. Neuroinflammation and oxidative reaction are among the pivotal factors for neurodegenerative...
15.
Bakar Z, Bellier J, Wan Ngah W, Yanagisawa D, Mukaisho K, Tooyama I
Cells
. 2023 Jan;
12(2).
PMID: 36672153
The precision of colocalization analysis is enhanced by 3D and is potentially more accurate than 2D. Even though 3D improves the visualization of colocalization analysis, rendering a colocalization model may...
16.
Chikugo A, Irie Y, Tsukano C, Uchino A, Maki T, Kume T, et al.
ACS Chem Neurosci
. 2022 Sep;
13(19):2913-2923.
PMID: 36095282
Since amyloid β (Aβ) oligomers are more cytotoxic than fibrils, various dimer models have been synthesized. We focused on the C-terminal region that could form a hydrophobic core in the...
17.
Matsuzaki Tada A, Hamezah H, Arrozi A, Bakar Z, Yanagisawa D, Tooyama I
J Alzheimers Dis
. 2022 Aug;
89(3):835-848.
PMID: 35964178
Background: Tripeptide Met-Lys-Pro (MKP), a component of casein hydrolysates, has effective angiotensin-converting enzyme (ACE) inhibitory activity. Brain angiotensin II enzyme activates the NADPH oxidase complex via angiotensin II receptor type...
18.
Synthesis and Characterization of Propeller- and Parallel-Type Full-Length Amyloid β40 Trimer Models
Uchino A, Irie Y, Tsukano C, Kawase T, Hirose K, Kageyama Y, et al.
ACS Chem Neurosci
. 2022 Aug;
13(16):2517-2528.
PMID: 35930616
Oligomers of the amyloid β (Aβ) protein play a critical role in the pathogenesis of Alzheimer's disease. However, their heterogeneity and lability deter the identification of their tertiary structures and...
19.
Shimizu S, Tojima I, Nakamura K, Kouzaki H, Kanesaka T, Ogawa N, et al.
Acta Histochem Cytochem
. 2022 Jul;
55(3):93-98.
PMID: 35821750
The pathological changes of Alzheimer's disease (AD) begin 10-20 years before clinical onset, and it is therefore desirable to identify effective methods for early diagnosis. The nasal mucosa is a...
20.
Takata K, Kimura H, Yanagisawa D, Harada K, Nishimura K, Kitamura Y, et al.
Molecules
. 2022 May;
27(9).
PMID: 35566132
Amyloid-β (Aβ) accumulation and tauopathy are considered the pathological hallmarks of Alzheimer's disease (AD), but attenuation in choline signaling, including decreased nicotinic acetylcholine receptors (nAChRs), is evident in the early...