Igor B Buchwalow
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Explore the profile of Igor B Buchwalow including associated specialties, affiliations and a list of published articles.
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33
Citations
367
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Recent Articles
1.
Rayo Abella L, Jacob H, Keller M, Schindler L, Pockes S, Pitzl S, et al.
J Pharmacol Exp Ther
. 2024 Mar;
389(2):174-185.
PMID: 38531640
There is a debate on whether H-histamine receptors can alter contractility in the mammalian heart. We studied here a new transgenic mouse model where we increased genetically the cardiac level...
2.
Rayo Abella L, Jacob H, Hesse C, Hofmann B, Schneider S, Schindler L, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 2024 Jan;
397(7):4939-4959.
PMID: 38177456
Dopamine can exert effects in the mammalian heart via five different dopamine receptors. There is controversy whether dopamine receptors increase contractility in the human heart. Therefore, we have generated mice...
3.
Gergs U, Jahn T, Schulz N, Grossmann C, Rueckschloss U, Demus U, et al.
Int J Mol Sci
. 2022 May;
23(9).
PMID: 35563079
Reversible protein phosphorylation is a posttranslational modification of regulatory proteins involved in cardiac signaling pathways. Here, we focus on the role of protein phosphatase 2A (PP2A) for cardiac gene expression...
4.
Neumann J, Bodicker K, Buchwalow I, Schmidbaur C, Ramos G, Frantz S, et al.
Mol Cell Biochem
. 2022 Mar;
477(6):1789-1801.
PMID: 35312907
Calsequestrin (CSQ2) is the main Ca-binding protein in the sarcoplasmic reticulum of the mammalian heart. In order to understand the function of calsequestrin better, we compared two age groups (young:...
5.
Dorner M, Boknik P, Kopp F, Buchwalow I, Neumann J, Gergs U
Int J Mol Sci
. 2021 Sep;
22(17).
PMID: 34502355
As part of our ongoing studies on the potential pathophysiological role of serine/threonine phosphatases (PP) in the mammalian heart, we have generated transgenic mice with cardiac muscle cell-specific overexpression of...
6.
Neumann J, Grobe J, Weisgut J, Schwelberger H, Fogel W, Marusakova M, et al.
Front Pharmacol
. 2021 May;
12:582916.
PMID: 34045955
Histamine is metabolized by several enzymes and . The relevance of this metabolism in the mammalian heart is unclear. However, histamine can exert positive inotropic effects (PIE) and positive chronotropic...
7.
Bollmann P, Werner F, Jaron M, Bruns T, Wache H, Runte J, et al.
Front Pharmacol
. 2021 Feb;
11:591773.
PMID: 33597873
As part of our ongoing studies on the potential pathophysiological role of serine/threonine phosphatases (PP) in the mammalian heart, we have generated mice with cardiac-specific overexpression of PP2Cβ (PP2C-TG) and...
8.
Krause T, Grote-Wessels S, Balzer F, Boknik P, Gergs U, Kirchhefer U, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 2018 May;
391(8):859-873.
PMID: 29797049
About half of the cardiac serine/threonine phosphatase activity is due to the activity of protein phosphatase type 1 (PP1). The activity of PP1 can be inhibited by an endogenous protein...
9.
Gergs U, Jung F, Buchwalow I, Hofmann B, Simm A, Treede H, et al.
Am J Physiol Heart Circ Physiol
. 2017 Sep;
313(6):H1087-H1097.
PMID: 28916638
Using transgenic (TG) mice that overexpress the human serotonin (5-HT) receptor specifically in cardiomyocytes, we wanted to know whether 5-HT can be formed and degraded in the mammalian heart and...
10.
Ponicke K, Gergs U, Buchwalow I, Hauptmann S, Neumann J
Mol Cell Biochem
. 2012 Feb;
365(1-2):301-12.
PMID: 22367115
Pleiotropic effects of serotonin (5-HT) in the cardiovascular system are well documented. However, it remains to be elucidated, whether 5-HT is present in adult mammalian cardiomyocytes. To address this issue,...