Ignacio E Sanchez
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Explore the profile of Ignacio E Sanchez including associated specialties, affiliations and a list of published articles.
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50
Citations
790
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Recent Articles
1.
Garcia-Montojo M, Fathi S, Rastegar C, Simula E, Doucet-OHare T, Cheng Y, et al.
Nat Commun
. 2024 May;
15(1):4163.
PMID: 38755145
TAR DNA-binding protein 43 (TDP-43) proteinopathy in brain cells is the hallmark of amyotrophic lateral sclerosis (ALS) but its cause remains elusive. Asparaginase-like-1 protein (ASRGL1) cleaves isoaspartates, which alter protein...
2.
Sanchez I, Galpern E, Ferreiro D
Proc Natl Acad Sci U S A
. 2024 May;
121(21):e2318905121.
PMID: 38739787
We propose that spontaneous folding and molecular evolution of biopolymers are two universal aspects that must concur for life to happen. These aspects are fundamentally related to the chemical composition...
3.
Hernandez Berthet A, Aptekmann A, Tejero J, Sanchez I, Noguera M, Roman E
Arch Biochem Biophys
. 2024 Apr;
755:109979.
PMID: 38583654
Although protein sequences encode the information for folding and function, understanding their link is not an easy task. Unluckily, the prediction of how specific amino acids contribute to these features...
4.
Aliperti L, Aptekmann A, Farfanuk G, Couso L, Soler-Bistue A, Sanchez I
Environ Microbiol
. 2023 Oct;
25(12):3255-3268.
PMID: 37813828
The guanine/cytosine (GC) content of prokaryotic genomes is species-specific, taking values from 16% to 77%. This diversity of selection for GC content remains contentious. We analyse the correlations between GC...
5.
Couso L, Soler-Bistue A, Aptekmann A, Sanchez I
Environ Microbiol
. 2023 Sep;
25(12):3052-3063.
PMID: 37658654
Microbes are often discussed in terms of dichotomies such as copiotrophic/oligotrophic and fast/slow-growing microbes, defined using the characterisation of microbial growth in isolated cultures. The dichotomies are usually qualitative and/or...
6.
Soler-Bistue A, Couso L, Sanchez I
Environ Microbiol
. 2023 Mar;
25(7):1232-1237.
PMID: 36856667
Nearly 100 years ago, Winogradsky published a classic communication in which he described two groups of microbes, zymogenic and autochthonous. When organic matter penetrates the soil, zymogenic microbes quickly multiply...
7.
Sanchez I, Galpern E, Garibaldi M, Ferreiro D
J Phys Chem B
. 2022 Oct;
126(43):8655-8668.
PMID: 36282961
We propose an application of molecular information theory to analyze the folding of single domain proteins. We analyze results from various areas of protein science, such as sequence-based potentials, reduced...
8.
Gonzalez-Foutel N, Glavina J, Borcherds W, Safranchik M, Barrera-Vilarmau S, Sagar A, et al.
Nat Struct Mol Biol
. 2022 Aug;
29(8):781-790.
PMID: 35948766
Many disordered proteins conserve essential functions in the face of extensive sequence variation, making it challenging to identify the mechanisms responsible for functional selection. Here we identify the molecular mechanism...
9.
Glavina J, Rodriguez de la Vega R, Risso V, Leonetti C, Chemes L, Sanchez I
J Mol Biol
. 2022 Mar;
434(10):167563.
PMID: 35351519
Over one hundred Mastadenovirus types infect seven orders of mammals. Virus-host coevolution may involve cospeciation, duplication, host switch and partial extinction events. We reconstruct Mastadenovirus diversification, finding that while cospeciation...
10.
Aptekmann A, Bulavka D, Nadra A, Sanchez I
PLoS One
. 2022 Jan;
17(1):e0263307.
PMID: 35089985
We study the limits imposed by transcription factor specificity on the maximum number of binding motifs that can coexist in a gene regulatory network, using the SwissRegulon Fantom5 collection of...