Ida Freda
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Explore the profile of Ida Freda including associated specialties, affiliations and a list of published articles.
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10
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34
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Recent Articles
1.
Costanzo A, Fata F, Freda I, De Sciscio M, Gugole E, Bulfaro G, et al.
Structure
. 2024 Jul;
32(9):1465-1476.e3.
PMID: 38971159
OleP is a bacterial cytochrome P450 involved in oleandomycin biosynthesis as it catalyzes regioselective epoxidation on macrolide intermediates. OleP has recently been reported to convert lithocholic acid (LCA) into murideoxycholic...
2.
Freda I, Exertier C, Barile A, Chaves-Sanjuan A, Vega M, Isupov M, et al.
Nucleic Acids Res
. 2023 Jun;
51(15):8237-8254.
PMID: 37378428
Specificity in protein-DNA recognition arises from the synergy of several factors that stem from the structural and chemical signatures encoded within the targeted DNA molecule. Here, we deciphered the nature...
3.
De Sciscio M, Nardi A, Parisi G, Bulfaro G, Costanzo A, Gugole E, et al.
Molecules
. 2023 Jan;
28(2).
PMID: 36677890
Cytochrome P450 OleP catalytic activity is strongly influenced by its structural dynamic conformational behavior. Here, we combine equilibrium-binding experiments with all-atom molecular dynamics simulations to clarify how different environments affect...
4.
Exertier C, Sebastiani F, Freda I, Gugole E, Cerutti G, Parisi G, et al.
ACS Chem Biol
. 2022 Jul;
17(8):2099-2108.
PMID: 35797699
We produced a neuroglobin variant, namely, Ngb CDless, with the excised CDloop- and D-helix, directly joining the C- and E-helices. The CDless variant retained bis-His hexacoordination, and we investigated the...
5.
Montemiglio L, Gugole E, Freda I, Exertier C, DAuria L, Chen C, et al.
Biomolecules
. 2022 Jan;
12(1).
PMID: 35053203
Substrate binding to the cytochrome P450 OleP is coupled to a large open-to-closed transition that remodels the active site, minimizing its exposure to the external solvent. When the aglycone substrate...
6.
Exertier C, Montemiglio L, Freda I, Gugole E, Parisi G, Savino C, et al.
Mol Aspects Med
. 2021 Dec;
84:101055.
PMID: 34876274
Neuroglobin is expressed in vertebrate brain and belongs to a branch of the globin family that diverged early in evolution. Sequence conservation and presence in nervous cells of several taxa...
7.
Cerutti G, Gugole E, Montemiglio L, Turbe-Doan A, Chena D, Navarro D, et al.
Biotechnol Biofuels
. 2021 Jul;
14(1):161.
PMID: 34294139
Background: Fungal glucose dehydrogenases (GDHs) are FAD-dependent enzymes belonging to the glucose-methanol-choline oxidoreductase superfamily. These enzymes are classified in the "Auxiliary Activity" family 3 (AA3) of the Carbohydrate-Active enZymes database,...
8.
Parisi G, Freda I, Exertier C, Cecchetti C, Gugole E, Cerutti G, et al.
Biomolecules
. 2020 Oct;
10(10).
PMID: 33036250
The cytochrome P450 OleP catalyzes the epoxidation of aliphatic carbons on both the aglycone 8.8a-deoxyoleandolide (DEO) and the monoglycosylated L-olivosyl-8.8a-deoxyoleandolide (L-O-DEO) intermediates of oleandomycin biosynthesis. We investigated the substrate versatility...
9.
Milazzo L, Exertier C, Becucci M, Freda I, Montemiglio L, Savino C, et al.
FEBS J
. 2020 Feb;
287(18):4082-4097.
PMID: 32034988
Different murine neuroglobin variants showing structural and dynamic alterations that are associated with perturbation of ligand binding have been studied: the CD loop mutants characterized by an enhanced flexibility (Gly-loop...
10.
Exertier C, Milazzo L, Freda I, Montemiglio L, Scaglione A, Cerutti G, et al.
Sci Rep
. 2019 Mar;
9(1):5326.
PMID: 30926858
Neuroglobin (Ngb) is predominantly expressed in neurons of the central and peripheral nervous systems and it clearly seems to be involved in neuroprotection. Engineering Ngb to observe structural and dynamic...