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Ida Chiara Guerrera

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Articles 79
Citations 932
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Recent Articles
1.
Raas Q, Haouy G, de Calbiac H, Pasho E, Marian A, Guerrera I, et al.
Cell Death Discov . 2025 Mar; 11(1):98. PMID: 40075110
Pathogenic mutations within the TBK1 gene leading to haploinsufficiency are causative of amyotrophic lateral sclerosis (ALS). This gene is linked to autophagy and inflammation, two cellular mechanisms reported to be...
2.
Zanetti A, Dujardin G, Fares-Taie L, Amiel J, Roger J, Audo I, et al.
Nat Commun . 2024 Nov; 15(1):10096. PMID: 39572588
Here we conduct a study involving 12 individuals with retinal dystrophy, neurological impairment, and skeletal abnormalities, with special focus on GPATCH11, a lesser-known G-patch domain-containing protein, regulator of RNA metabolism....
3.
Dias C, Ballout N, Morla G, Alileche K, Santiago C, Guerrera I, et al.
Mol Med . 2024 Nov; 30(1):197. PMID: 39497064
Background: In mucopolysaccharidosis type III (MPS III, also known as Sanfilippo syndrome), a pediatric neurodegenerative disorder, accumulation of abnormal glycosaminoglycans (GAGs) induces severe neuroinflammation by triggering the microglial pro-inflammatory cytokines...
4.
Khelifa A, Bhaskaran M, Boissavy T, Mouveaux T, Silva T, Chhuon C, et al.
PLoS Biol . 2024 Sep; 22(9):e3002791. PMID: 39255306
Virulence of apicomplexan parasites is based on their ability to divide rapidly to produce significant biomass. The regulation of their cell cycle is therefore key to their pathogenesis. Phosphorylation is...
5.
Bakouh N, Castano-Martin R, Metais A, Dan E, Balducci E, Chhuon C, et al.
Brain . 2024 Aug; 148(2):549-563. PMID: 39106285
Focal cortical dysplasia, hemimegalencephaly and cortical tubers are paediatric epileptogenic malformations of cortical development (MCDs) frequently pharmacoresistant and mostly treated surgically by the resection of epileptic cortex. Availability of cortical...
6.
Dang T, Maufrais C, Colin J, Moyrand F, Mouyna I, Coppee J, et al.
PLoS Biol . 2024 Jul; 22(7):e3002724. PMID: 39052688
Alternative transcription start site (TSS) usage regulation has been identified as a major means of gene expression regulation in metazoans. However, in fungi, its impact remains elusive as its study...
7.
Brigant B, Metzinger-Le Meuth V, Boyartchuk V, Ouled-Haddou H, Guerrera I, Rochette J, et al.
Bone . 2024 Jul; 187:117205. PMID: 39019132
MULIBREY nanism which results from autosomal recessive mutations in TRIM37 impacts skeletal development, leading to growth delay with complications in multiple organs. In this study, we employed a combined proteomics...
8.
Zhu S, Waeckel-Enee E, Oshima M, Moser A, Bessard M, Gdoura A, et al.
iScience . 2024 May; 27(6):109929. PMID: 38799566
Tuning of protein homeostasis through mobilization of the unfolded protein response (UPR) is key to the capacity of pancreatic beta cells to cope with variable demand for insulin. Here, we...
9.
Rytter H, Roger K, Chhuon C, Ding X, Coureuil M, Jamet A, et al.
Sci Rep . 2024 Apr; 14(1):7797. PMID: 38565565
Bacterial pathogens adapt and replicate within host cells, while host cells develop mechanisms to eliminate them. Using a dual proteomic approach, we characterized the intra-macrophage proteome of the facultative intracellular...
10.
Le Ribeuz H, Willer A, Chevalier B, Sancho M, Masson B, Eyries M, et al.
Am J Respir Cell Mol Biol . 2024 Mar; 71(1):95-109. PMID: 38546978
Pulmonary arterial (PA) hypertension (PAH) is a severe cardiopulmonary disease that may be triggered by exposure to drugs such as dasatinib or facilitated by genetic predispositions. The incidence of dasatinib-associated...