Ian R A Mackenzie
Overview
Explore the profile of Ian R A Mackenzie including associated specialties, affiliations and a list of published articles.
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Articles
92
Citations
7947
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Recent Articles
1.
Casaletto K, Saloner R, Kornak J, Staffaroni A, Villeda S, Paolillo E, et al.
Brain Commun
. 2025 Jan;
7(1):fcae432.
PMID: 39816189
The largest risk factor for dementia is age. Heterochronic blood exchange studies have uncovered age-related blood factors that demonstrate 'pro-aging' or 'pro-youthful' effects on the mouse brain. The clinical relevance...
2.
Lee H, Cheung S, Perneel J, Rademakers R, Hsiung G, Mackenzie I
Acta Neuropathol
. 2025 Jan;
149(1):7.
PMID: 39812821
No abstract available.
3.
Kovacs G, Grinberg L, Halliday G, Alafuzoff I, Dugger B, Murayama S, et al.
Mov Disord
. 2024 Oct;
39(12):2173-2179.
PMID: 39360851
No abstract available.
4.
Forgrave L, Moon K, Hamden J, Li Y, Lu P, Foster L, et al.
Alzheimers Dement
. 2023 Jul;
20(1):103-111.
PMID: 37461300
Introduction: Biomarkers of TDP-43 pathology are needed to distinguish frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) from phenotypically related disorders. While normal physiological TDP-43 is not a promising biomarker, low-resolution...
5.
Neumann M, Perneel J, Cheung S, Van den Broeck M, Nygaard H, Hsiung G, et al.
Acta Neuropathol
. 2023 May;
146(1):163-166.
PMID: 37171635
No abstract available.
6.
Vicente C, Perneel J, Wynants S, Heeman B, Van den Broeck M, Baker M, et al.
Brain
. 2023 Apr;
146(10):4055-4064.
PMID: 37100087
Transmembrane protein 106B (TMEM106B) is a tightly regulated glycoprotein predominantly localized to endosomes and lysosomes. Genetic studies have implicated TMEM106B haplotypes in the development of multiple neurodegenerative diseases with the...
7.
Lee H, Mackenzie I, Beg M, Popuri K, Rademakers R, Wittenberg D, et al.
Brain Commun
. 2023 Jan;
5(1):fcac333.
PMID: 36632182
A large proportion of familial frontotemporal dementia is caused by TAR DNA-binding protein 43 (transactive response DNA-binding protein 43 kDa) proteinopathies. Accordingly, carriers of autosomal dominant mutations in the genes...
8.
Perneel J, Neumann M, Heeman B, Cheung S, Van den Broeck M, Wynants S, et al.
Acta Neuropathol
. 2023 Jan;
145(3):369-370.
PMID: 36607424
No abstract available.
9.
Perneel J, Neumann M, Heeman B, Cheung S, Van den Broeck M, Wynants S, et al.
Acta Neuropathol
. 2022 Dec;
145(3):285-302.
PMID: 36527486
Several studies using cryogenic electron microscopy (cryo-EM) techniques recently reported the isolation and characterization of novel protein filaments, composed of a C-terminal fragment (CTF) of the endolysosomal transmembrane protein 106B...
10.
Tartaglia M, Mackenzie I
Can J Neurol Sci
. 2022 May;
50(4):485-494.
PMID: 35634749
Frontotemporal dementia (FTD) is a devastating neurodegenerative condition for which there is currently no effective treatment. Although it is much less common than Alzheimer's disease, the impact of FTD is...