Ian Goodhead
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Explore the profile of Ian Goodhead including associated specialties, affiliations and a list of published articles.
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34
Citations
4979
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Recent Articles
1.
Kuderna L, Ulirsch J, Rashid S, Ameen M, Sundaram L, Hickey G, et al.
Nature
. 2023 Nov;
625(7996):735-742.
PMID: 38030727
Noncoding DNA is central to our understanding of human gene regulation and complex diseases, and measuring the evolutionary sequence constraint can establish the functional relevance of putative regulatory elements in...
2.
Kuderna L, Gao H, Janiak M, Kuhlwilm M, Orkin J, Bataillon T, et al.
Science
. 2023 Jun;
380(6648):906-913.
PMID: 37262161
The rich diversity of morphology and behavior displayed across primate species provides an informative context in which to study the impact of genomic diversity on fundamental biological processes. Analysis of...
3.
Gao H, Hamp T, Ede J, Schraiber J, McRae J, Singer-Berk M, et al.
Science
. 2023 Jun;
380(6648):eabn8153.
PMID: 37262156
Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding of their clinical relevance remains largely incomplete. To systematically decipher the effects of human genetic variants,...
4.
Gao H, Hamp T, Ede J, Schraiber J, McRae J, Singer-Berk M, et al.
bioRxiv
. 2023 May;
PMID: 37205491
One Sentence Summary: Deep learning classifier trained on 4.3 million common primate missense variants predicts variant pathogenicity in humans.
5.
Harrison X, McDevitt A, Dunn J, Griffiths S, Benvenuto C, Birtles R, et al.
Proc Biol Sci
. 2021 Aug;
288(1957):20210552.
PMID: 34403636
Interactions between hosts and their resident microbial communities are a fundamental component of fitness for both agents. Though recent research has highlighted the importance of interactions between animals and their...
6.
Goodhead I, Blow F, Brownridge P, Hughes M, Kenny J, Krishna R, et al.
Microb Genom
. 2020 Jan;
6(1).
PMID: 31922467
The majority of bacterial genomes have high coding efficiencies, but there are some genomes of intracellular bacteria that have low gene density. The genome of the endosymbiont contains almost 50 ...
7.
Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa
Bricio-Moreno L, Sheridan V, Goodhead I, Armstrong S, Wong J, Waters E, et al.
Nat Commun
. 2018 Jul;
9(1):2635.
PMID: 29980663
Pseudomonas aeruginosa colonises the upper airway of cystic fibrosis (CF) patients, providing a reservoir of host-adapted genotypes that subsequently establish chronic lung infection. We previously experimentally-evolved P. aeruginosa in a...
8.
Bronowski C, Mustafa K, Goodhead I, James C, Nelson C, Lucaci A, et al.
PLoS One
. 2017 Dec;
12(11):e0188936.
PMID: 29190673
Background: Water serves as a potential reservoir for Campylobacter, the leading cause of bacterial gastroenteritis in humans. However, little is understood about the mechanisms underlying variations in survival characteristics between...
9.
Antwis R, Griffiths S, Harrison X, Aranega-Bou P, Arce A, Bettridge A, et al.
FEMS Microbiol Ecol
. 2017 Apr;
93(5).
PMID: 28379446
Microbial ecology provides insights into the ecological and evolutionary dynamics of microbial communities underpinning every ecosystem on Earth. Microbial communities can now be investigated in unprecedented detail, although there is...
10.
Noyes H, Daly D, Goodhead I, Kay S, Kemp S, Kenny J, et al.
BMC Genomics
. 2015 Aug;
16:642.
PMID: 26311067
Background: Almost all genome sequencing projects neglect the fact that diploid organisms contain two genome copies and consequently what is published is a composite of the two. This means that...