Ian C Zachary
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Explore the profile of Ian C Zachary including associated specialties, affiliations and a list of published articles.
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37
Citations
1434
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Recent Articles
1.
Critchley W, Smith G, Zachary I, Harrison M, Ponnambalam S
J Cell Sci
. 2023 May;
136(10).
PMID: 37226882
Vascular endothelial growth factor receptor 2 (VEGFR2, encoded by KDR) regulates endothelial function and angiogenesis. VEGFR2 undergoes ubiquitination that programs this receptor for trafficking and proteolysis, but the ubiquitin-modifying enzymes...
2.
Critchley W, Fearnley G, Abdul-Zani I, Molina-Paris C, Bendtsen C, Zachary I, et al.
Methods Mol Biol
. 2022 Apr;
2475:113-124.
PMID: 35451752
The endothelial response to vascular endothelial growth factor A (VEGF-A) regulates many aspects of animal physiology in health and disease. Such VEGF-A-regulated phenomena include vasculogenesis, angiogenesis, tumor growth and progression....
3.
Mota F, Yelland T, Hutton J, Parker J, Patsiarika A, Chan A, et al.
Chembiochem
. 2021 Oct;
23(1):e202100463.
PMID: 34647407
Vascular endothelial growth factors (VEGFs) regulate significant pathways in angiogenesis, myocardial and neuronal protection, metabolism, and cancer progression. The VEGF-B growth factor is involved in cell survival, anti-apoptotic and antioxidant...
4.
Lowe V, Wisniewski L, Sayers J, Evans I, Frankel P, Mercader-Huber N, et al.
Development
. 2019 Jun;
146(13).
PMID: 31167777
Unlike adult mammals, zebrafish can regenerate their heart. A key mechanism for regeneration is the activation of the epicardium, leading to the establishment of a supporting scaffold for new cardiomyocytes,...
5.
Bubb K, Aubdool A, Moyes A, Lewis S, Drayton J, Tang O, et al.
Circulation
. 2018 Dec;
139(13):1612-1628.
PMID: 30586761
Background: Angiogenesis and vascular remodeling are complementary, innate responses to ischemic cardiovascular events, including peripheral artery disease and myocardial infarction, which restore tissue blood supply and oxygenation; the endothelium plays...
6.
Powell J, Mota F, Steadman D, Soudy C, Miyauchi J, Crosby S, et al.
J Med Chem
. 2018 Apr;
61(9):4135-4154.
PMID: 29648813
We report the design, synthesis, and biological evaluation of some potent small-molecule neuropilin-1 (NRP1) antagonists. NRP1 is implicated in the immune response to tumors, particularly in Treg cell fragility, required...
7.
Critchley W, Pellet-Many C, Ringham-Terry B, Harrison M, Zachary I, Ponnambalam S
Cells
. 2018 Mar;
7(3).
PMID: 29543760
Receptor tyrosine kinases (RTKs) are membrane-based sensors that enable rapid communication between cells and their environment. Evidence is now emerging that interdependent regulatory mechanisms, such as membrane trafficking, ubiquitination, proteolysis...
8.
Evans I, Kennedy S, Paliashvili K, Santra T, Yamaji M, Lovering R, et al.
Mol Cell Proteomics
. 2016 Dec;
16(2):168-180.
PMID: 28007913
p130Cas is a polyvalent adapter protein essential for cardiovascular development, and with a key role in cell movement. In order to identify the pathways by which p130Cas exerts its biological...
9.
Frolov A, Evans I, Li N, Sidlauskas K, Paliashvili K, Lockwood N, et al.
Sci Rep
. 2016 Jun;
6:27378.
PMID: 27293031
Imatinib was the first targeted tyrosine kinase inhibitor to be approved for clinical use, and remains first-line therapy for Philadelphia chromosome (Ph+)-positive chronic myelogenous leukaemia. We show that treatment of...
10.
Carr D, Wallace J, Aitken R, Milne J, Martin J, Zachary I, et al.
Biol Reprod
. 2016 Apr;
94(6):142.
PMID: 27103444
Uterine artery (UtA) adenovirus (Ad) vector-mediated overexpression of vascular endothelial growth factor (VEGF) enhances uterine blood flow in normal sheep pregnancy and increases fetal growth in the overnourished adolescent sheep...