Ian C MacArthur
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Explore the profile of Ian C MacArthur including associated specialties, affiliations and a list of published articles.
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12
Citations
289
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Recent Articles
1.
MacArthur I, Ma L, Huang C, Bhavsar H, Suzuki M, Dawlaty M
Sci Adv
. 2024 Aug;
10(35):eado5424.
PMID: 39196941
DNA methylation is extensively reconfigured during development, but the functional significance and cell type-specific dependencies of DNA demethylation in lineage specification remain poorly understood. Here, we demonstrate that developmental DNA...
2.
Dorado Garcia H, Pusch F, Bei Y, von Stebut J, Ibanez G, Guillan K, et al.
Nat Commun
. 2022 Jul;
13(1):4297.
PMID: 35879366
Despite advances in multi-modal treatment approaches, clinical outcomes of patients suffering from PAX3-FOXO1 fusion oncogene-expressing alveolar rhabdomyosarcoma (ARMS) remain dismal. Here we show that PAX3-FOXO1-expressing ARMS cells are sensitive to...
3.
MacArthur R, Bentur O, MacArthur I, Bartoo A, Capozzi D, Christensen J, et al.
J Clin Transl Sci
. 2021 Jun;
5(1):e108.
PMID: 34192062
Introduction: In March 2020, academic medical center (AMC) pharmacies were compelled to implement practice changes in response to the COVID-19 pandemic. These changes were described by survey data collected by...
4.
MacArthur I, Dawlaty M
Front Cell Dev Biol
. 2021 Mar;
9:645335.
PMID: 33681230
Studies of tissue-specific epigenomes have revealed 5-hydroxymethylcytosine (5hmC) to be a highly enriched and dynamic DNA modification in the metazoan nervous system, inspiring interest in the function of this epigenetic...
5.
Henssen A, Koche R, Zhuang J, Jiang E, Reed C, Eisenberg A, et al.
Nat Genet
. 2020 Sep;
52(11):1265.
PMID: 32918070
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
6.
Koche R, Rodriguez-Fos E, Helmsauer K, Burkert M, MacArthur I, Maag J, et al.
Nat Genet
. 2020 Feb;
52(4):464.
PMID: 32107479
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
7.
Timme N, Han Y, Liu S, Yosief H, Dorado Garcia H, Bei Y, et al.
Transl Oncol
. 2019 Dec;
13(2):221-232.
PMID: 31869746
Simultaneous inhibition of multiple molecular targets is an established strategy to improve the continuance of clinical response to therapy. Here, we screened 49 molecules with dual nanomolar inhibitory activity against...
8.
Koche R, Rodriguez-Fos E, Helmsauer K, Burkert M, MacArthur I, Maag J, et al.
Nat Genet
. 2019 Dec;
52(1):29-34.
PMID: 31844324
Extrachromosomal circularization of DNA is an important genomic feature in cancer. However, the structure, composition and genome-wide frequency of extrachromosomal circular DNA have not yet been profiled extensively. Here, we...
9.
MacArthur I, Bei Y, Dorado Garcia H, Ortiz M, Toedling J, Klironomos F, et al.
JCI Insight
. 2019 Apr;
5.
PMID: 30998507
Gain of the long arm of chromosome 17 (17q) is a cytogenetic hallmark of high-risk neuroblastoma, yet its contribution to neuroblastoma pathogenesis remains incompletely understood. Combining whole-genome and RNA sequencing...
10.
Henssen A, Reed C, Jiang E, Dorado Garcia H, von Stebut J, MacArthur I, et al.
Sci Transl Med
. 2017 Nov;
9(414).
PMID: 29093183
Despite intense efforts, the cure rates of childhood and adult solid tumors are not satisfactory. Resistance to intensive chemotherapy is common, and targets for molecular therapies are largely undefined. We...