I Saranya
Overview
Explore the profile of I Saranya including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
19
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Recent Articles
1.
Kolipaka R, Magesh I, Karthik S, Ashok Bharathy M, Saranya I, Preetha D, et al.
Exp Ther Med
. 2024 Dec;
29(1):20.
PMID: 39624592
Transforming growth factor beta 1 (TGF-β1), a multifunctional cytokine, induces the expression of bone remodeling gene matrix metalloproteinase-13 (MMP-13). CREB-binding protein (CBP), a co-activator and runt-related transcription factor 2 (Runx2),...
2.
Kolipaka R, Magesh I, Ashok Bharathy M, Karthik S, Saranya I, Selvamurugan N
Noncoding RNA Res
. 2024 Apr;
9(3):687-694.
PMID: 38577015
Cells produce short single-stranded non-coding RNAs (ncRNAs) called microRNAs (miRNAs), which actively regulate gene expression at the posttranscriptional level. Several miRNAs have been observed to exert significant impacts on bone...
3.
Saranya I, Dharshini V, Akshaya R, Subhashini P, Selvamurugan N
Int J Biol Macromol
. 2024 Mar;
266(Pt 2):131075.
PMID: 38531528
Breast cancer (BC) is a global health concern, and development of diagnostic tools and targeted treatments for BC remains challenging. Therapeutic approaches for BC often involve a combination of surgery,...
4.
Akshaya R, Saranya I, Salomi G, Shanthi P, Ilangovan R, Venkataraman P, et al.
J Cancer Res Clin Oncol
. 2024 Feb;
150(2):63.
PMID: 38300343
Purpose: Skeletal metastases are increasingly reported in metastatic triple-negative breast cancer (BC) patients. We previously reported that TGF-β1 sustains activating transcription factor 3(ATF3) expression and is required for cell proliferation,...
5.
Saranya I, Akshaya R, Gomathi K, Mohanapriya R, He Z, Partridge N, et al.
Noncoding RNA Res
. 2023 Nov;
9(1):153-164.
PMID: 38035043
Transforming growth factor-beta1 (TGF-β1) stimulates matrix metalloproteinase-13 (, a bone-remodeling gene) expression, and this effect requires p300-mediated Runx2 (Runt-related transcription factor 2) acetylation in osteoblasts. p300 and Runx2 are transcriptional...
6.
Akshaya R, Saranya I, Selvamurugan N
Breast Cancer
. 2023 Aug;
30(6):910-925.
PMID: 37578597
Breast cancer (BC) bone metastasis is primarily osteolytic and has limited therapeutic options. Metastasized BC cells prime the secondary environment in bone by forming a tumor niche, which favors their...
7.
Hari Krishnan R, Sadu L, Akshaya R, Gomathi K, Saranya I, Das U, et al.
Int J Biol Macromol
. 2022 Nov;
225:1152-1163.
PMID: 36427609
Parathyroid hormone (PTH) regulates the expression of bone remodeling genes by enhancing the activity of Runx2 in osteoblasts. p300, a histone acetyltransferase, acetylated Runx2 to activate the expression of its...
8.
Saranya I, Akshaya R, Selvamurugan N
Differentiation
. 2022 Nov;
128:57-66.
PMID: 36370525
Bone is a rigid, mineralized connective tissue that constitutes part of the skeleton in most vertebrate animals. Bone remodeling is a complex process that involves the coordination of ossification and...
9.
Hari Krishnan R, Sadu L, Das U, Satishkumar S, Pranav Adithya S, Saranya I, et al.
Differentiation
. 2022 Feb;
124:43-51.
PMID: 35180610
Bone is a dynamic and tough connective tissue that undergoes constant remodeling throughout life. Bone-forming osteoblasts respond to various hormones, cytokines, and growth factors, and synthesize extracellular matrix components. Runx2...