I R Lemischka
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Explore the profile of I R Lemischka including associated specialties, affiliations and a list of published articles.
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33
Citations
1783
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Recent Articles
1.
MacArthur B, Maayan A, Lemischka I
Cold Spring Harb Symp Quant Biol
. 2009 Mar;
73:211-5.
PMID: 19329576
The last few years have seen significant advances in our understanding of the molecular mechanisms of stem-cell-fate specification. New and emerging high-throughput techniques, as well as increasingly accurate loss-of-function perturbation...
2.
Nolta J, Thiemann F, Arakawa-Hoyt J, Dao M, Barsky L, Moore K, et al.
Leukemia
. 2002 Mar;
16(3):352-61.
PMID: 11896538
The immortalized murine stromal cell line AFT024 has been reported to maintain human hematopoietic progenitors in an undifferentiated state in vitro. In the current studies the beige/nude/xid (bnx) mouse in...
3.
Lewis I, Almeida-Porada G, Du J, Lemischka I, Moore K, Zanjani E, et al.
Blood
. 2001 May;
97(11):3441-9.
PMID: 11369635
This report describes stroma-based and stroma-free cultures that maintain long-term engrafting hematopoietic cells for at least 14 days ex vivo. Umbilical cord blood (UCB) CD34(+) cells were cultured in transwells...
4.
5.
Phillips R, Ernst R, Brunk B, Ivanova N, Mahan M, Deanehan J, et al.
Science
. 2000 Jun;
288(5471):1635-40.
PMID: 10834841
Blood cell production originates from a rare population of multipotent, self-renewing stem cells. A genome-wide gene expression analysis was performed in order to define regulatory pathways in stem cells as...
6.
Petrenko O, Beavis A, Klaine M, Kittappa R, Godin I, Lemischka I
Immunity
. 1999 Jul;
10(6):691-700.
PMID: 10403644
We have identified and characterized the stem cell antigen AA4. This molecule is a type I transmembrane protein whose overall structure suggests a role in cell adhesion. During fetal ontogeny...
7.
Punzel M, Wissink S, Miller J, Moore K, Lemischka I, Verfaillie C
Blood
. 1999 May;
93(11):3750-6.
PMID: 10339481
Hematopoietic stem cells (HSC) are cells with self-renewing multilineage differentiation potential. Although engraftment in xenogeneic recipients can be used to measure human HSC, these assays do not allow assessment of...
8.
Punzel M, Moore K, Lemischka I, Verfaillie C
Leukemia
. 1999 Feb;
13(1):92-7.
PMID: 10049066
The goal of this study was to evaluate if differences in culture conditions used in long-term culture assays affect enumeration of LTC-IC in freshly sorted or ex vivo expanded CD34+/HLA-DRdim/CD2-/CD7-...
9.
Miller J, McCullar V, Punzel M, Lemischka I, Moore K
Blood
. 1998 Dec;
93(1):96-106.
PMID: 9864151
Marrow stromal cultures support adult CD34(+)/Lin-/HLA-DR- or CD34(+)/Lin-/CD38(-) cell differentiation into natural killer (NK) or myeloid cells, but unlike committed lymphoid progenitors (CD34(+)/Lin-/CD45RA+/CD10(+)), no B cells are generated. We tested...
10.
Thiemann F, Moore K, Smogorzewska E, Lemischka I, Crooks G
Exp Hematol
. 1998 Jul;
26(7):612-9.
PMID: 9657136
A stromal cell line derived from murine fetal liver (AFT024) has been demonstrated to maintain long-term repopulating murine stem cells for up to 7 weeks in vitro. We evaluated the...