I J McFadyen
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Explore the profile of I J McFadyen including associated specialties, affiliations and a list of published articles.
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20
Citations
82
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Recent Articles
1.
A randomized double blind-cross over trial of soya protein for the treatment of cyclical breast pain
McFadyen I, Chetty U, Setchell K, Zimmer-Nechemias L, Stanley E, Miller W
Breast
. 2004 Jan;
9(5):271-6.
PMID: 14732177
Twenty patients with cyclical breast pain were enrolled in a double-blind cross-over trial in which either a soy protein drink or a flavoured cow's milk was taken orally each day...
2.
McFadyen I, Metzger T, Paterlini M, Ferguson D
Protein Eng
. 2002 Jan;
14(12):953-60.
PMID: 11809925
Previous studies have probed the structural basis of ligand selectivity in the mu, delta and kappa opioid receptors through the application of molecular modeling techniques in concert with the 'message-address'...
3.
Alt A, McFadyen I, Fan C, Woods J, Traynor J
J Pharmacol Exp Ther
. 2001 Jun;
298(1):116-21.
PMID: 11408532
The guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding assay for the determination of relative opioid efficacy has been adapted to measure G protein activation in digitonin-permeabilized C6 rat glioma cells expressing a cloned mu-opioid...
4.
McFadyen I, Schaefer M, Ho J, Omnaas J, Mosberg H, Traynor J
J Pharmacol Exp Ther
. 2000 Nov;
295(3):960-6.
PMID: 11082429
The Phe(1) cyclic tetrapeptide Phe-c[D-Cys-Phe-D-Pen]NH(2) (Et) (JH-54) has been shown previously to exhibit high affinity and selectivity for the mu-opioid receptor. To examine the role of the Phe(1) residue in...
5.
McFadyen I, Houshyar H, Liu-Chen L, Woods J, Traynor J
Mol Pharmacol
. 2000 Sep;
58(4):669-76.
PMID: 10999935
The steroid SC17599 (17alpha-acetoxy-6-dimethylaminomethyl-21-fluoro-3-ethoxypregna -3, 5-dien-20-one) has mu-opioid actions in vivo. The ability of SC17599 to interact with opioid receptors has been studied using radioligand and [(35)S]guanosine-5'-O-(3-thio)triphosphate (GTPgammaS) binding assays....
6.
Characterization of ZFOR1, a putative delta-opioid receptor from the teleost zebrafish (Danio rerio)
Rodriguez R, Barrallo A, McFadyen I, Gonzalez-Sarmiento R, Traynor J
Neurosci Lett
. 2000 Jul;
288(3):207-10.
PMID: 10889344
ZFOR1 is a putative opioid receptor from zebrafish brain which has 66% homology with the mammalian delta-opioid receptor. When expressed in HEK293 cells ZFOR1 bound the non-selective opioid antagonist [(3)H]diprenorphine...
7.
McFadyen I, Ho J, Mosberg H, Traynor J
J Pept Res
. 2000 Mar;
55(3):255-61.
PMID: 10727108
The previously described cyclic mu opioid receptor-selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]NH2 (Et) (JOM-6) was modified at residues 1 and 3 by substitution with various natural and synthetic amino acids, and/or by alteration...
8.
Wang C, McFadyen I, Traynor J, Mosberg H
Bioorg Med Chem Lett
. 1999 Jan;
8(19):2685-8.
PMID: 9873603
A pair of diastereomeric peptidomimetics based upon opioid receptor-binding pharmacophore models derived for a series of opioid tetrapeptides was synthesized. Both analogues display high opioid receptor affinity, moderate selectivity for...
9.
McFadyen I, Raab G, Macintyre C, Forrest A
BMJ
. 1989 Apr;
298(6678):931.
PMID: 2497864
No abstract available.
10.
McFadyen I, Bolton A, Cameron E, Hunter W, Raab G, Forrest A
Clin Endocrinol (Oxf)
. 1980 Jul;
13(1):77-86.
PMID: 6777090
Plasma levels of LH, FSH, oestradiol 17 beta and testosterone were measured in twenty-two men with gynaecomastia. The group was divided by age into those under and those over 50-years-old...