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I A Nieduszynski

Explore the profile of I A Nieduszynski including associated specialties, affiliations and a list of published articles. Areas
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Citations 528
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Recent Articles
1.
Lauder R, Huckerby T, Brown G, Bayliss M, Nieduszynski I
Biochem J . 2001 Aug; 358(Pt 2):523-8. PMID: 11513754
The chondroitin sulphate (CS) linkage regions have been isolated from human articular cartilage aggrecan (from 10- to 72-year-olds) by chondroitin ABC endolyase digestion and size-exclusion chromatography. Linkage region hexasaccharides have...
2.
Huckerby T, Lauder R, Brown G, Nieduszynski I, Anderson K, Boocock J, et al.
Eur J Biochem . 2001 Mar; 268(5):1181-9. PMID: 11231269
Chondroitin sulfates were fragmented using the enzymes chondroitin sulfate ABC endolyase and chondroitin ACII lyase; both disaccharide and tetrasaccharide fragments were isolated after reduction to the corresponding 2-deoxy-2-N-acetylamino-D-galactitol (GalNAc-ol) form....
3.
Lauder R, Huckerby T, Nieduszynski I
Glycobiology . 2000 Apr; 10(4):393-401. PMID: 10764827
A previously published method for the analysis of glycosaminoglycan disaccharides by high pH anion exchange chromatography (Midura,R.J., Salustri,A., Calabro,A., Yanagishita,M. and Hascall,V.C. (1994), Glycobiology,4, 333-342) has been modified and calibrated...
4.
Lauder R, Huckerby T, Nieduszynski I
Biochem J . 2000 Apr; 347(Pt 2):339-48. PMID: 10749661
We report the isolation, characterization and quantification of five octasaccharides, four hexasaccharides and two tetrasaccharides, derived from the chondroitin sulphate (CS) linkage region of 6-8-year-old bovine articular cartilage aggrecan, following...
5.
Lewis D, Davies Y, Nieduszynski I, Lawrence F, Quantock A, Bonshek R, et al.
Glycobiology . 2000 Mar; 10(3):305-12. PMID: 10704529
Keratan sulfate (KS) proteoglycans are of importance for the maintenance of corneal transparency as evidenced in the condition macular corneal dystrophy type I (MCD I), a disorder involving the absence...
6.
Huckerby T, Nieduszynski I, Bayliss M, Brown G
Eur J Biochem . 1999 Dec; 266(3):1174-83. PMID: 10583415
The use of high-field two-dimensional 1H-correlation data is described for the detailed comparison of intact keratan sulfate polymer chains derived from human articular cartilage sources as a function of age....
7.
Davies Y, Lewis D, Fullwood N, Nieduszynski I, Marcyniuk B, Albon J, et al.
Exp Eye Res . 1999 Mar; 68(3):303-11. PMID: 10079138
Proteoglycans are of fundamental importance to the normal functioning of the cornea. They consist of a core protein to which one or more glycosaminoglycan chains are attached. Cell surface proteoglycans...
8.
Whitham K, Hadley J, Morris H, Andrew S, Nieduszynski I, Brown G
Glycobiology . 1999 Feb; 9(3):285-91. PMID: 10024666
A previously developed method for the structural fingerprinting of keratan sulfates (Brown et al., Glycobiology, 5, 311-317, 1995) has been adapted for use with oligosaccharides fluorescently labeled with 2-aminobenzoic acid...
9.
Huckerby T, Lauder R, Nieduszynski I
Eur J Biochem . 1999 Jan; 258(2):669-76. PMID: 9874233
Five octasaccharides derived from the protein carbohydrate linkage region of chondroitin sulphate (CS) have been isolated from the large aggregating proteoglycan (aggrecan) extracted from the bovine articular cartilage of 6-year-old...
10.
Brown G, Huckerby T, Bayliss M, Nieduszynski I
J Biol Chem . 1998 Oct; 273(41):26408-14. PMID: 9756873
Alkaline borohydride-reduced keratan sulfate chains were isolated from human articular cartilage aggrecan from individuals of various ages (0-85 years old). The chains were structurally characterized using 1H NMR spectroscopy, gel...