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Huoming Huang

Explore the profile of Huoming Huang including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 15
Followers 0
Related Specialties
Chemistry
Neurology
Anesthesiology
Top 10 Co-Authors
Wei Li
Xuejun Xu
Yujun Wang
Wei Fu
Jinggen Liu
Yuanyuan Qian
Wenli Wang
Xinwei Li
Chen Zhu
Congmin Yuan
Published In
J Med Chem
Front Cardiovasc Med
Eur J Med Chem
BMC Anesthesiol
ACS Chem Neurosci
Affiliations
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Recent Articles
1.
Esketamine and neurocognitive disorders in adult surgical patients: a meta-analysis
Lin X, Liu X, Huang H, Xu X, Zhang T, Gao J
BMC Anesthesiol . 2024 Dec; 24(1):448. PMID: 39639216
Background: Prior meta-analyses have established the potential of intravenous ketamine in safeguarding against neurocognitive impairment, but the efficacy of intravenous esketamine for the prevention of perioperative neurocognitive disorders (PND) remains...
2.
Estimated pulse wave velocity is associated with all-cause and cardio-cerebrovascular disease mortality in stroke population: Results from NHANES (2003-2014)
Huang H, Bu X, Pan H, Yang S, Cheng W, Shubhra Q, et al.
Front Cardiovasc Med . 2023 May; 10:1140160. PMID: 37153456
Background: Arterial stiffness is a significant determinant and evaluation of cardio-cerebrovascular disease and all-cause mortality risk in the stroke population. Estimated pulse wave velocity (ePWV) is a well-established indirect measure...
3.
Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3,4)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic
Huang H, Li X, Xie P, Li X, Xu X, Qian Y, et al.
J Med Chem . 2021 Jun; 64(13):9458-9483. PMID: 34152138
Management of moderate to severe pain relies heavily on opioid analgesics such as morphine, oxycodone, and fentanyl in clinics. However, their prolonged use was associated with undesirable side effects. Many...
4.
Design, Synthesis, and Structure-Activity Relationship Exploration of Alkyl/Phenylalkyl Piperidine Analogues as Novel Highly Potent and Selective μ Opioid Receptor Agonists
Huang H, Li X, Guo W, Zhu C, Qian Y, Shen Q, et al.
ACS Chem Neurosci . 2020 Aug; 12(2):285-299. PMID: 32852933
Pain was implicated in many diseases. Despite effectiveness to treat moderate to severe pain, opioid analgesics elicited many side effects, greatly limiting their prescription in clinics. Based on , an...
5.
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic
Huang H, Wang W, Xu X, Zhu C, Wang Y, Liu J, et al.
Eur J Med Chem . 2020 Jan; 189:112070. PMID: 31982651
Management of moderate to severe pain by clinically used opioid analgesics is associated with a plethora of side effects. Despite many efforts have been dedicated to reduce undesirable side effects,...
6.
Discovery of a Highly Selective and Potent κ Opioid Receptor Agonist from -Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept
Xiao L, Wang Y, Zhang M, Wu W, Kong L, Ma Y, et al.
J Med Chem . 2019 Nov; 62(24):11054-11070. PMID: 31738550
Effective and safe analgesics represent an unmet medical need for the treatment of acute and chronic pain. A series of -cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaines were designed, synthesized, and assayed, leading to the discovery...