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Hung-Ping Shih

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Articles 13
Citations 196
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Recent Articles
1.
Filipowska J, Cisneros Z, Varghese S, Leon-Rivera N, Wang P, Kang R, et al.
Mol Metab . 2025 Jan; 92:102097. PMID: 39788290
Objective: Loss of functional β-cell mass is a major cause of diabetes. Thus, identifying regulators of β-cell health is crucial for treating this disease. The Leucine-rich repeat-containing G-protein-coupled receptor (GPCR)...
2.
Parveen N, Wang J, Bhattacharya S, Cuala J, Singh Rajkumar M, Butler A, et al.
Diabetes . 2023 Sep; 72(12):1882. PMID: 37683666
No abstract available.
3.
Gonzalez N, Kato H, Tixi W, Ortiz J, Orr C, Shih H, et al.
Cell Transplant . 2023 Jun; 32:9636897231182497. PMID: 37345228
"Firefly rats" ubiquitously express the luciferase reporter gene under the control of constitutively active promoter in inbred Lewis rats. Due to the minimal immunogenicity of luciferase, wide applications of Firefly...
4.
Kozlowski M, Zook H, Chigumba D, Johnstone C, Caldera L, Shih H, et al.
Front Bioeng Biotechnol . 2023 Mar; 11:1144209. PMID: 36970620
The transplantation of pancreatic endocrine islet cells from cadaveric donors is a promising treatment for type 1 diabetes (T1D), which is a chronic autoimmune disease that affects approximately nine million...
5.
Parveen N, Wang J, Bhattacharya S, Cuala J, Singh Rajkumar M, Butler A, et al.
Diabetes . 2023 Jan; 72(5):575-589. PMID: 36607262
The molecular and functional heterogeneity of pancreatic β-cells is well recognized, but the underlying mechanisms remain unclear. Pancreatic islets harbor a subset of β-cells that co-express tyrosine hydroxylase (TH), an...
6.
Maldonado M, Serrill J, Shih H
Methods Mol Biol . 2020 Jun; 2155:193-200. PMID: 32474878
The pancreas is composed of different cellular populations, organized into distinct functional units, including acinar clusters, islets of Langerhans, and the ductal system. As a result of research into diabetes,...
7.
Vinckier N, Patel N, Geusz R, Wang A, Wang J, Matta I, et al.
Nat Commun . 2020 May; 11(1):2082. PMID: 32350257
Developmental progression depends on temporally defined changes in gene expression mediated by transient exposure of lineage intermediates to signals in the progenitor niche. To determine whether cell-intrinsic epigenetic mechanisms contribute...
8.
Jin W, Mulas F, Gaertner B, Sui Y, Wang J, Matta I, et al.
iScience . 2019 Nov; 21:681-694. PMID: 31733514
Pancreatic endocrine cell differentiation is orchestrated by the action of transcription factors that operate in a gene regulatory network to activate endocrine lineage genes and repress lineage-inappropriate genes. MicroRNAs (miRNAs)...
9.
Jin L, Gao D, Feng T, Tremblay J, Ghazalli N, Luo A, et al.
Stem Cell Res . 2015 Dec; 16(1):40-53. PMID: 26691820
Progenitor cells in the adult pancreas are potential sources of endocrine beta cells for treating type 1 diabetes. Previously, we identified tri-potent progenitor cells in the adult (2-4month-old) murine pancreas...
10.
Eng D, Ma H, Xu J, Shih H, Gross M, Kioussi C, et al.
PLoS One . 2012 Aug; 7(7):e42228. PMID: 22860089
Sequence specific transcription factors (SSTFs) combinatorially define cell types during development by forming recursively linked network kernels. Pitx2 expression begins during gastrulation, together with Hox genes, and becomes localized to...