Humberto Milani
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Explore the profile of Humberto Milani including associated specialties, affiliations and a list of published articles.
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56
Citations
520
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Recent Articles
1.
de Oliveira R, Kohara N, Milani H
Int Rev Neurobiol
. 2024 Jul;
177:95-120.
PMID: 39029992
The absence of blood flow in cerebral ischemic conditions triggers a multitude of intricate pathophysiological mechanisms, including excitotoxicity, oxidative stress, neuroinflammation, disruption of the blood-brain barrier and white matter disarrangement....
2.
Mattos B, Bonato J, Splendor M, Del Bel E, Milani H, de Oliveira R
Acta Neuropsychiatr
. 2024 May;
36(5):307-319.
PMID: 38770713
Objective: To investigate the effects of cannabidiol (CBD) on emotional and cognitive symptoms in rats with intra-nigral 6-hydroxydopamine (6-OHDA) lesions. Methods: Adult male Wistar rats received bilateral intranigral 6-OHDA infusions...
3.
Bonato J, Mattos B, Oliveira D, Milani H, Prickaerts J, de Oliveira R
Neurotox Res
. 2023 Mar;
41(4):311-323.
PMID: 36922461
Phosphodiesterase 4 inhibitors (PDE4-I), which selectively increase cyclic adenosine monophosphate (cAMP) levels, have shown neuroprotective effects after several neurological injuries inducing blood-brain barrier (BBB) damage including local/focal cerebral ischemia. The...
4.
Estuani J, Godinho J, Borges S, Neves C, Milani H, Buttow N
Tissue Cell
. 2023 Feb;
81:102033.
PMID: 36764059
Aims: Brain ischemia and reperfusion may occur in several clinical conditions that have high rates of mortality and disability, compromising an individual's quality of life. Brain injury can affect organs...
5.
Aguiar R, Soares L, Varney M, Newman-Tancredi A A, Milani H, Prickaerts J, et al.
Neurobiol Aging
. 2023 Feb;
124:52-59.
PMID: 36739621
5-HT serotonin receptors may play a role in cognitive function changes related to advanced age. Here, we investigated the effects of acute and repeated treatment with NLX-101 (F15599), a postsynaptic...
6.
de Oliveira D, Godinho J, de Sa-Nakanishi A, Fernando Comar J, de Oliveira R, Bonato J, et al.
J Ethnopharmacol
. 2023 Jan;
306:116176.
PMID: 36682600
Ethnopharmacological Relevance: Trichilia catigua A. Juss (Meliaceae) is used in Brazilian folk medicine to alleviate fatigue and emotional stress and improve memory. Previous studies from our laboratory reported that an...
7.
Vilhena E, Bonato J, Schepers M, Kunieda J, Milani H, Vanmierlo T, et al.
Behav Pharmacol
. 2021 Jul;
32(6):459-471.
PMID: 34320520
Inhibition of phosphodiesterase 4 (PDE4) is a promising pharmacological strategy for the treatment of cerebral ischemic conditions. To increase the relevance and increase the translational value of preclinical studies, it...
8.
Meyer E, Bonato J, Mori M, Mattos B, Guimaraes F, Milani H, et al.
Mol Neurobiol
. 2021 Jul;
58(10):5338-5355.
PMID: 34302281
Evidence for the clinical use of neuroprotective drugs for the treatment of cerebral ischemia (CI) is still greatly limited. Spatial/temporal disorientation and cognitive dysfunction are among the most prominent long-term...
9.
Mori M, Meyer E, da Silva F, Milani H, Guimaraes F, Oliveira R
Eur J Neurosci
. 2021 Feb;
53(6):1738-1751.
PMID: 33522084
An ever-increasing body of preclinical studies has shown the multifaceted neuroprotective profile of cannabidiol (CBD) against impairments caused by cerebral ischemia. In this study, we have explored the neuropharmacological mechanisms...
10.
Bonato J, Meyer E, de Mendonca P, Milani H, Prickaerts J, de Oliveira R
Eur J Neurosci
. 2020 Dec;
53(4):1171-1188.
PMID: 33340424
Phosphodiesterase 4 (PDE4) inhibitors have been shown to present beneficial effects in cerebral ischemic injury because of their ability to improve cognition and target different phases and mechanisms of cerebral...