Hugh R Matthews
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Explore the profile of Hugh R Matthews including associated specialties, affiliations and a list of published articles.
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27
Citations
486
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Recent Articles
1.
Rodriguez M, Morris J, Bardsley O, Matthews H, Huang C
Front Physiol
. 2024 Dec;
15:1468333.
PMID: 39703671
Introduction: Intracellular Ca signalling regulates membrane permeabilities, enzyme activity, and gene transcription amongst other functions. Large transmembrane Ca electrochemical gradients and low diffusibility between cell compartments potentially generate short-lived, localised,...
2.
Leslie T, Tripp A, James A, Fraser S, Nelson M, Sajjaboontawee N, et al.
Oncogene
. 2024 Jul;
43(34):2578-2594.
PMID: 39048659
Solid tumours have abnormally high intracellular [Na]. The activity of various Na channels may underlie this Na accumulation. Voltage-gated Na channels (VGSCs) have been shown to be functionally active in...
3.
Bertagna F, Ahmad S, Lewis R, Silva S, McFadden J, Huang C, et al.
Front Physiol
. 2024 May;
15:1359560.
PMID: 38720787
Introduction: The loose-patch clamp technique was first developed and used in native amphibian skeletal muscle (SkM), offering useful features complementing conventional sharp micro-electrode, gap, or conventional patch voltage clamping. It...
4.
Bertagna F, Ahmad S, Lewis R, Silva S, McFadden J, Huang C, et al.
Ann N Y Acad Sci
. 2024 Apr;
1535(1):62-75.
PMID: 38602714
Hippocampal pyramidal neuronal activity has been previously studied using conventional patch clamp in isolated cells and brain slices. We here introduce the loose patch clamping study of voltage-activated currents from...
5.
Morris J, Bardsley O, Salvage S, Jackson A, Matthews H, Huang C
Front Physiol
. 2024 Jan;
14:1280151.
PMID: 38235384
In addition to gap junction conduction, recent reports implicate possible ephaptic coupling contributions to action potential (AP) propagation between successive adjacent cardiomyocytes. Here, AP generation in an active cell, withdraws...
6.
Salvage S, Habib Z, Matthews H, Jackson A, Huang C
Biochem Soc Trans
. 2021 Oct;
49(5):1941-1961.
PMID: 34643236
Voltage-dependent Na+ channel activation underlies action potential generation fundamental to cellular excitability. In skeletal and cardiac muscle this triggers contraction via ryanodine-receptor (RyR)-mediated sarcoplasmic reticular (SR) Ca2+ release. We here...
7.
Bardsley O, Matthews H, Huang C
Sci Rep
. 2021 Jul;
11(1):14376.
PMID: 34257321
A finite element analysis modelled diffusional generation of steady-state Ca microdomains within skeletal muscle transverse (T)-tubular-sarcoplasmic reticular (SR) junctions, sites of ryanodine receptor (RyR)-mediated SR Ca release. It used established...
8.
Liu S, Matthews H, Huang C
Sci Rep
. 2021 Feb;
11(1):2846.
PMID: 33531589
Skeletal muscle Na channels possess Ca- and calmodulin-binding sites implicated in Nav1.4 current (I) downregulation following ryanodine receptor (RyR1) activation produced by exchange protein directly activated by cyclic AMP or...
9.
Sarbjit-Singh S, Matthews H, Huang C
Sci Rep
. 2020 Feb;
10(1):2199.
PMID: 32042141
We investigated effects of the ryanodine receptor (RyR) modulator caffeine on Na current (I) activation and inactivation in intact loose-patch clamped murine skeletal muscle fibres subject to a double pulse...
10.
Matthews H, Tan S, Shoesmith J, Ahmad S, Valli H, Jeevaratnam K, et al.
Sci Rep
. 2019 Feb;
9(1):1927.
PMID: 30760734
We investigated effects of pharmacological triggering of exchange protein directly activated by cyclic-3',5'-adenosine monophosphate (Epac) on Nav1.4 currents from intact murine (C67BL6) skeletal muscle fibres for the first time. This...