Hugh McDevitt
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Explore the profile of Hugh McDevitt including associated specialties, affiliations and a list of published articles.
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10
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Recent Articles
1.
Hung J, Liao J, Lin Y, Chang H, Wu S, Chang T, et al.
J Autoimmun
. 2005 Nov;
25(3):181-92.
PMID: 16263243
To improve the feasibility of in vivo monitoring of autoreactive T cells in the diabetogenic process, we generated T1 and T2 doubly transgenic non-obese diabetic (NOD) mice in which transgenic...
2.
Masteller E, Warner M, Tang Q, Tarbell K, McDevitt H, Bluestone J
J Immunol
. 2005 Aug;
175(5):3053-9.
PMID: 16116193
CD4+CD25+Foxp3+ regulatory T cells (T(reg)) are critical for controlling autoimmunity. Evidence suggests that T(reg) development, peripheral maintenance, and suppressive function are dependent on Ag specificity. However, there is little direct...
3.
4.
McDevitt H
Proc Natl Acad Sci U S A
. 2004 Oct;
101 Suppl 2:14627-30.
PMID: 15466699
Specific antigen vaccination by administration of the target antigen in aqueous solution has resulted in significant decreases of disease severity in animal models of experimental allergic encephalomyelitis, type I diabetes,...
5.
Tang Q, Henriksen K, Bi M, Finger E, Szot G, Ye J, et al.
J Exp Med
. 2004 Jun;
199(11):1455-65.
PMID: 15184499
The low number of CD4+ CD25+ regulatory T cells (Tregs), their anergic phenotype, and diverse antigen specificity present major challenges to harnessing this potent tolerogenic population to treat autoimmunity and...
6.
McDevitt H
Ann N Y Acad Sci
. 2003 Dec;
1005:75-81.
PMID: 14679041
Using BW 5147 T cell hybridomas isolated by fusion with spleen and lymph node cells from NOD female mice, two T cell receptor transgenic NOD mouse lines were produced. Both...
7.
Pedotti R, Sanna M, Tsai M, Devoss J, Steinman L, McDevitt H, et al.
BMC Immunol
. 2003 Feb;
4:2.
PMID: 12597780
Background: Insulin dependent (i.e., "type 1") diabetes mellitus (T1DM) is considered to be a T cell mediated disease in which TH1 and Tc autoreactive cells attack the pancreatic islets. Among...
8.
McDevitt H
Immunol Rev
. 2002 Aug;
185:78-85.
PMID: 12190924
Immunization of rabbits, and inbred strains of mice with branched, multichain, synthetic polypeptides, such as (T, G) - A--L and (H, G) - A--L, revealed striking differences in the ability...
9.
Tarbell K, Lee M, Ranheim E, Chao C, Sanna M, Kim S, et al.
J Exp Med
. 2002 Aug;
196(4):481-92.
PMID: 12186840
Glutamic acid decarboxylase (GAD)65 is an early and important antigen in both human diabetes mellitus and the nonobese diabetic (NOD) mouse. However, the exact role of GAD65-specific T cells in...
10.
McDevitt H, Munson S, Ettinger R, Wu A
Arthritis Res
. 2002 Jul;
4 Suppl 3:S141-52.
PMID: 12110133
Tumor necrosis factor (TNF)-alpha and lymphotoxin (LT) alpha/beta play multiple roles in the development and function of the immune system. This article focuses on three important aspects of the effects...