Hugh B Manning
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Explore the profile of Hugh B Manning including associated specialties, affiliations and a list of published articles.
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10
Citations
176
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Recent Articles
1.
Manning H, Nickdel M, Yamamoto K, Lagarto J, Kelly D, Talbot C, et al.
Matrix Biol
. 2012 Dec;
32(1):32-8.
PMID: 23266527
Cartilage is a vital organ to maintain joint function. Upon arthritis, proteolytic enzymes initiate degradation of cartilage extracellular matrix (ECM) resulting in eventual loss of joint function. However, there are...
2.
Everett K, Buehler A, Bunney T, Margineanu A, Baxendale R, Vatter P, et al.
Mol Cell Biol
. 2011 Jan;
31(6):1240-51.
PMID: 21245382
We performed analyses of the molecular mechanisms involved in the regulation of phospholipase Cγ2 (PLCγ2). We identified several regions in the PLCγ-specific array, γSA, that contribute to autoinhibition in the...
3.
Ushakov D, Caorsi V, Ibanez-Garcia D, Manning H, Konitsiotis A, West T, et al.
J Biol Chem
. 2010 Nov;
286(1):842-50.
PMID: 21056977
We applied fluorescence lifetime imaging microscopy to map the microenvironment of the myosin essential light chain (ELC) in permeabilized skeletal muscle fibers. Four ELC mutants containing a single cysteine residue...
4.
Kennedy G, Manning H, Elson D, Neil M, Stamp G, Viellerobe B, et al.
J Biophotonics
. 2009 Sep;
3(1-2):103-7.
PMID: 19787682
We describe a fluorescence lifetime imaging endomicroscope employing a fibre bundle probe and time correlated single photon counting. Preliminary images of stained pollen grains, eGFP-labelled cells exhibiting Förster resonant energy...
5.
Manning H, Kennedy G, Owen D, Grant D, Magee A, Neil M, et al.
J Biophotonics
. 2009 Apr;
1(6):494-505.
PMID: 19343675
We report a novel, compact and automated multidimensional spectrofluorometer that exploits a fibre-laser-pumped ultrafast supercontinuum source to provide resolution with respect to intensity, excitation and emission wavelength, decay time and...
6.
Miller M, Manning H, Jain A, Troeberg L, Dudhia J, Essex D, et al.
Arthritis Rheum
. 2009 Feb;
60(3):686-97.
PMID: 19248098
Objective: A hallmark of rheumatoid arthritis (RA) is invasion of the synovial pannus into cartilage, and this process requires degradation of the collagen matrix. The aim of this study was...
7.
Robinson T, Valluri P, Manning H, Owen D, Munro I, Talbot C, et al.
Opt Lett
. 2008 Aug;
33(16):1887-9.
PMID: 18709122
Fluorescence lifetime imaging (FLIM) is used to quantitatively map the concentration of a small molecule in three dimensions in a microfluidic mixing device. The resulting experimental data are compared with...
8.
Poher V, Kennedy G, Manning H, Owen D, Zhang H, Gu E, et al.
Opt Lett
. 2008 Aug;
33(16):1813-5.
PMID: 18709096
We describe a simple implementation of a slit scanning confocal microscope to obtain an axial resolution better than that of a point-scanning confocal microscope. Under slit illumination, images of a...
9.
Owen D, Auksorius E, Manning H, Talbot C, De Beule P, Dunsby C, et al.
Opt Lett
. 2007 Dec;
32(23):3408-10.
PMID: 18059949
We present a time-gated, optically sectioned, hyperspectral fluorescence lifetime imaging (FLIM) microscope incorporating a tunable supercontinuum excitation source extending into the UV. The system is capable of resolving the excitation...
10.
De Beule P, Owen D, Manning H, Talbot C, Requejo-Isidro J, Dunsby C, et al.
Microsc Res Tech
. 2007 Mar;
70(5):481-4.
PMID: 17366615
We report a rapid hyperspectral fluorescence lifetime imaging (FLIM) instrument that exploits high-speed FLIM technology in a line-scanning microscope. We demonstrate the acquisition of whole-field optically sectioned hyperspectral fluorescence lifetime...