Huayun Shi
Overview
Explore the profile of Huayun Shi including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
307
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Recent Articles
1.
Shi H, Mohan M, Singh K, Sadler P
RSC Adv
. 2025 Feb;
15(5):3168-3171.
PMID: 39896429
Photoactive diazido Pt(iv) complexes display anticancer efficacy towards oesophageal tumours, a worldwide common cancer. Here we explore the use of optical coherence tomography (OCT) as a new method for detecting...
2.
Shi H, Marchi R, Sadler P
Angew Chem Int Ed Engl
. 2025 Jan;
64(9):e202423335.
PMID: 39806815
Photoactivatable metal complexes offer the prospect of novel drugs with low side effects and new mechanisms of action to combat resistance to current therapy. We highlight recent progress in the...
3.
Shi H, Ward-Deitrich C, Ponte F, Sicilia E, Goenaga-Infante H, Sadler P
Dalton Trans
. 2024 Jul;
53(31):13044-13054.
PMID: 39028324
The hyphenation of HPLC with its high separation ability and ICP-MS with its excellent sensitivity, allows the analysis of Pt drugs in biological samples at the low nanomolar concentration levels....
4.
Shi H, Carter O, Ponte F, Imberti C, Gomez-Gonzalez M, Cacho-Nerin F, et al.
Angew Chem Int Ed Engl
. 2024 Apr;
63(23):e202400476.
PMID: 38656762
The novel hetero-dinuclear complex trans,trans,trans-[Pt(py)(N)(OH)(μ-OOCCHCHCONHCH-bpyMe)Ir(ppy)]Cl (Pt-Ir), exhibits charge transfer between the acceptor photochemotherapeutic Pt(IV) (Pt-OH) and donor photodynamic Ir(III) (Ir-NH) fragments. It is stable in the dark, but undergoes photodecomposition...
5.
Shi H, Ponte F, Grewal J, Clarkson G, Imberti C, Hands-Portman I, et al.
Chem Sci
. 2024 Mar;
15(11):4121-4134.
PMID: 38487220
Photoactive prodrugs offer potential for spatially-selective antitumour activity with minimal effects on normal tissues. Excited-state chemistry can induce novel effects on biochemical pathways and combat resistance to conventional drugs. Photoactive...
6.
Wang F, Prokes I, Song L, Shi H, Sadler P
J Biol Inorg Chem
. 2022 Sep;
27(8):695-704.
PMID: 36153767
Determination of the toxicity of compounds toward cancer cells is a frequent procedure in drug discovery. For metal complexes, which are often reactive prodrugs, care has to be taken to...
7.
Bolitho E, Sanchez-Cano C, Shi H, Quinn P, Harkiolaki M, Imberti C, et al.
J Am Chem Soc
. 2021 Nov;
143(48):20224-20240.
PMID: 34808054
The Pt(IV) prodrug -[Pt(pyridine)(N)(OH)] () and its coumarin derivative -[Pt(pyridine)(N)(OH)(coumarin-3-carboxylate)] () are promising agents for photoactivated chemotherapy. These complexes are inert in the dark but release Pt(II) species and radicals...
8.
Anthony E, Bolitho E, Bridgewater H, Carter O, Donnelly J, Imberti C, et al.
Chem Sci
. 2021 Jun;
11(48):12888-12917.
PMID: 34123239
Metals play vital roles in nutrients and medicines and provide chemical functionalities that are not accessible to purely organic compounds. At least 10 metals are essential for human life and...
9.
Shi H, Kasparkova J, Soulie C, Clarkson G, Imberti C, Novakova O, et al.
Chemistry
. 2021 May;
27(41):10711-10716.
PMID: 34046954
Photoactivatable agents offer the prospect of highly selective cancer therapy with low side effects and novel mechanisms of action that can combat current drug resistance. 1,8-Naphthalimides with their extended π...
10.
Shi H, Imberti C, Clarkson G, Sadler P
Inorg Chem Front
. 2021 Mar;
7(19):3533-3540.
PMID: 33786191
Mono-axial functionalised octahedral diazido Pt(iv) complexes trans, trans, trans-[Pt(py)(N)(OR)(OR)] (OR = OH and OR = anticancer agent coumarin-3 carboxylate (cou, ), pyruvate dehydrogenase kinase (PDK) inhibitors 4-phenylbutyrate (PhB, ) or...