Huaxiang Tong
Overview
Explore the profile of Huaxiang Tong including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
231
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Recent Articles
1.
Allen C, Kortagere S, Tong H, Matthiesen R, Metzger J, Wiemer D, et al.
Mol Pharmacol
. 2017 Jan;
91(3):229-236.
PMID: 28057800
The isoprenoid donor for protein geranylgeranylation reactions, geranylgeranyl diphosphate (GGDP), is the product of the enzyme GGDP synthase (GGDPS) that condenses farnesyl diphosphate (FDP) and isopentenyl pyrophosphate. GGDPS inhibition is...
2.
Dykstra K, Allen C, Born E, Tong H, Holstein S
Oncotarget
. 2015 Nov;
6(39):41535-49.
PMID: 26595805
Multiple myeloma (MM) is characterized by the production of monoclonal protein (MP). We have shown previously that disruption of the isoprenoid biosynthetic pathway (IBP) causes a block in MP secretion...
3.
Reilly J, Neighbors J, Tong H, Henry M, Hohl R
Clin Exp Metastasis
. 2015 Jun;
32(6):555-66.
PMID: 26070429
The isoprenoid biosynthetic pathway (IBP) is critical for providing substrates for the post-translational modification of proteins key in regulating malignant cell properties, including proliferation, invasion, and migration. Inhibitors of the...
4.
Reilly J, Zhou X, Tong H, Kuder C, Wiemer D, Hohl R
Biochem Pharmacol
. 2015 May;
96(2):83-92.
PMID: 25952057
A small set of isoprenoid bisphosphonates ethers has been tested in the K562 chronic myelogenous leukemia cell line to determine their impact on isoprenoid biosynthesis. Five of these compounds inhibit...
5.
Zhou X, Ferree S, Wills V, Born E, Tong H, Wiemer D, et al.
Bioorg Med Chem
. 2014 Apr;
22(9):2791-8.
PMID: 24726306
When inhibitors of enzymes that utilize isoprenoid pyrophosphates are based on the natural substrates, a significant challenge can be to achieve selective inhibition of a specific enzyme. One element in...
6.
Tong H, Kuder C, Wasko B, Hohl R
Anal Biochem
. 2012 Sep;
433(1):36-42.
PMID: 23000003
Isopentenyl diphosphate (IPP), an intermediate of the isoprenoid biosynthetic pathway (IBP), has several important biological functions, yet a method to determine its basal level has not been described. Here, we...
7.
Holstein S, Kuder C, Tong H, Hohl R
Lipids
. 2011 Jun;
46(10):907-21.
PMID: 21633866
The schweinfurthins, a family of natural products derived from the isoprenoid biosynthetic pathway (IBP), have marked growth inhibitory activity. However, the biochemical basis for the schweinfurthins cellular effects has remained...
8.
Dudakovic A, Tong H, Hohl R
Invest New Drugs
. 2010 May;
29(5):912-20.
PMID: 20480384
The objective of this study was to determine whether geranylgeranyl diphosphate synthase inhibition, and therefore geranylgeranyl diphosphate depletion, interferes with breast cancer cell migration. Digeranyl bisphosphonate is a specific geranylgeranyl...
9.
Holstein S, Tong H, Kuder C, Hohl R
Lipids
. 2009 Oct;
44(11):1055-62.
PMID: 19856009
Geranyl diphosphate (GPP), a 10-carbon isoprenoid, is a key intermediate in the isoprenoid biosynthetic pathway. This pathway, in addition to leading to sterol synthesis, results in the synthesis of farnesyl...
10.
Holstein S, Tong H, Hohl R
Leuk Res
. 2009 Aug;
34(3):344-51.
PMID: 19646757
Thalidomide has emerged as an effective agent for treating multiple myeloma, however the precise mechanism of action remains unknown. Agents known to target the isoprenoid biosynthetic pathway (IBP) can have...