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Hsiao-Lin Lee

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Articles 18
Citations 155
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Recent Articles
1.
Wu C, Li H, Li W, Hsu C, Yang W, Chuang G, et al.
STAR Protoc . 2024 Dec; 5(4):103478. PMID: 39644497
2-deoxy-D-glucose (2DG) is a glucose analog converted to 2-deoxy-D-glucose-6-phosphate (2DG-6P) by hexokinase in glycolysis. While 2DG commonly measures glucose uptake, 2DG-6P detects glucose utilization. Here, we present a protocol to...
2.
Chang Y, Lee H, Yang W, Hsieh M, Liu C, Lee T, et al.
Nat Commun . 2023 Sep; 14(1):5971. PMID: 37749090
Obesity and type 2 diabetes have reached pandemic proportion. ALDH2 (acetaldehyde dehydrogenase 2, mitochondrial) is the key metabolizing enzyme of acetaldehyde and other toxic aldehydes, such as 4-hydroxynonenal. A missense...
3.
Chang Y, Hsu C, Chong K, Yang P, Ser K, Lee P, et al.
Obes Surg . 2023 Aug; 33(10):3035-3050. PMID: 37612578
Background: The superior effects of gastric bypass surgery in preventing cardiovascular diseases compared with sleeve gastrectomy are well-established. However, whether these effects are independent of weight loss is not known....
4.
Yang W, Chuang G, Che T, Chueh L, Li W, Hsu C, et al.
Am J Nephrol . 2023 Jul; 54(9-10):359-369. PMID: 37437553
Introduction: Chronic kidney disease, which is defined by a reduced estimated glomerular filtration rate and albuminuria, imposes a large health burden worldwide. Ethnicity-specific associations are frequently observed in genome-wide association...
5.
Hsu C, Hsuan C, Liao D, Chang J, Chang A, Hee S, et al.
Life (Basel) . 2023 Apr; 13(4). PMID: 37109553
Diabetic patients have a two- to four-fold increase in the risk of heart failure (HF), and the co-existence of diabetes and HF is associated with poor prognosis. In randomized clinical...
6.
Hsuan C, Teng S, Hsu C, Liao D, Chang A, Lee H, et al.
Biomedicines . 2023 Mar; 11(3). PMID: 36979641
Diabetic cardiomyopathy is characterized by abnormal myocardial structure or performance in the absence of coronary artery disease or significant valvular heart disease in patients with diabetes mellitus. The spectrum of...
7.
Chiu C, Hsuan C, Lin S, Hung Y, Hwu C, Hee S, et al.
J Biomed Sci . 2023 Feb; 30(1):13. PMID: 36803854
Background: Genome-wide association studies (GWASs) have linked RRBP1 (ribosomal-binding protein 1) genetic variants to atherosclerotic cardiovascular diseases and serum lipoprotein levels. However, how RRBP1 regulates blood pressure is unknown. Methods:...
8.
Liu P, Chuang G, Hsiung C, Yang W, Ku H, Lin Y, et al.
Sci Rep . 2022 May; 12(1):8025. PMID: 35577822
Melatonin exerts a wide range of effects among various tissues and organs. However, there is currently no study to investigate the genetic determinants of melatonin secretion. Here, we conducted a...
9.
Lee H, Hee S, Hsuan C, Yang W, Huang J, Lin Y, et al.
Antioxidants (Basel) . 2021 Apr; 10(3). PMID: 33805825
Diabetes mellitus has reached epidemic proportion worldwide. One of the diabetic complications is cardiomyopathy, characterized by early left ventricular (LV) diastolic dysfunction, followed by development of systolic dysfunction and ventricular...
10.
Chuang G, Liu P, Chyan T, Huang C, Huang Y, Lin C, et al.
Sci Rep . 2020 Sep; 10(1):14578. PMID: 32884031
Fibroblast growth factors (FGFs) 21 and 23 are recently identified hormones regulating metabolism of glucose, lipid, phosphate and vitamin D. Here we conducted a genome-wide association study (GWAS) for circulating...