Howard R Katz
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Explore the profile of Howard R Katz including associated specialties, affiliations and a list of published articles.
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26
Citations
1019
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Recent Articles
1.
Dwyer D, Ordovas-Montanes J, Allon S, Buchheit K, Vukovic M, Derakhshan T, et al.
Sci Immunol
. 2021 Feb;
6(56).
PMID: 33637594
Mast cells (MCs) play a pathobiologic role in type 2 (T2) allergic inflammatory diseases of the airway, including asthma and chronic rhinosinusitis with nasal polyposis (CRSwNP). Distinct MC subsets infiltrate...
2.
Buchheit K, Dwyer D, Ordovas-Montanes J, Katz H, Lewis E, Vukovic M, et al.
J Allergy Clin Immunol
. 2020 Mar;
145(6):1574-1584.
PMID: 32199912
Background: The cause of severe nasal polyposis in aspirin-exacerbated respiratory disease (AERD) is unknown. Elevated antibody levels have been associated with disease severity in nasal polyps, but upstream drivers of...
3.
Liu T, Barrett N, Kanaoka Y, Buchheit K, Laidlaw T, Garofalo D, et al.
Mucosal Immunol
. 2019 Jan;
12(3):679-690.
PMID: 30664709
Cysteinyl leukotrienes (cysLTs) facilitate eosinophilic mucosal type 2 immunopathology, especially in aspirin-exacerbated respiratory disease (AERD), by incompletely understood mechanisms. We now demonstrate that platelets, activated through the type 2 cysLT...
4.
Ordovas-Montanes J, Dwyer D, Nyquist S, Buchheit K, Vukovic M, Deb C, et al.
Nature
. 2018 Aug;
560(7720):649-654.
PMID: 30135581
Barrier tissue dysfunction is a fundamental feature of chronic human inflammatory diseases. Specialized subsets of epithelial cells-including secretory and ciliated cells-differentiate from basal stem cells to collectively protect the upper...
5.
Cahill K, Katz H, Cui J, Lai J, Kazani S, Crosby-Thompson A, et al.
N Engl J Med
. 2017 May;
376(20):1911-1920.
PMID: 28514613
Background: Mast cells are present in the airways of patients who have severe asthma despite glucocorticoid treatment; these cells are associated with disease characteristics including poor quality of life and...
6.
Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity
Lee M, Yoshimoto E, Saijo S, Iwakura Y, Lin X, Katz H, et al.
J Immunol
. 2016 May;
197(1):278-87.
PMID: 27194783
The C-type lectin receptor Dectin-2 can trigger the leukotriene C4 synthase-dependent generation of cysteinyl leukotrienes and the caspase-associated recruitment domain 9- and NF-κB-dependent generation of cytokines, such as IL-23, IL-6,...
7.
Buchheit K, Cahill K, Katz H, Murphy K, Feng C, Lee-Sarwar K, et al.
J Allergy Clin Immunol
. 2015 Dec;
137(5):1566-1576.e5.
PMID: 26691435
Background: Prostaglandin (PG) D2 is the dominant COX product of mast cells and is an effector of aspirin-induced respiratory reactions in patients with aspirin-exacerbated respiratory disease (AERD). Objective: We evaluated...
8.
Liu T, Kanaoka Y, Barrett N, Feng C, Garofalo D, Lai J, et al.
J Immunol
. 2015 Sep;
195(8):3537-45.
PMID: 26342029
Aspirin-exacerbated respiratory disease (AERD), a severe eosinophilic inflammatory disorder of the airways, involves overproduction of cysteinyl leukotrienes (cysLTs), activation of airway mast cells (MCs), and bronchoconstriction in response to nonselective...
9.
Parsons M, Li L, Wallace A, Lee M, Katz H, Fernandez J, et al.
J Immunol
. 2014 Jan;
192(4):1361-71.
PMID: 24453247
The myeloid C-type lectin receptor Dectin-2 directs the generation of Th2 and Th17 immune responses to the house dust mite Dermatophagoides farinae through the generation of cysteinyl leukotrienes and proinflammatory...
10.
Liu T, Laidlaw T, Katz H, Boyce J
Proc Natl Acad Sci U S A
. 2013 Oct;
110(42):16987-92.
PMID: 24085850
Aspirin-exacerbated respiratory disease (AERD) is characterized by asthma, tissue eosinophilia, overproduction of cysteinyl leukotrienes (cysLTs), and respiratory reactions to nonselective cyclooxygenase (COX) inhibitors. Ex vivo studies suggest that functional abnormalities...