Howard Cann
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Explore the profile of Howard Cann including associated specialties, affiliations and a list of published articles.
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10
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1492
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Recent Articles
1.
Bergstrom A, McCarthy S, Hui R, Almarri M, Ayub Q, Danecek P, et al.
Science
. 2020 Mar;
367(6484).
PMID: 32193295
Genome sequences from diverse human groups are needed to understand the structure of genetic variation in our species and the history of, and relationships between, different populations. We present 929...
2.
Henn B, Botigue L, Peischl S, Dupanloup I, Lipatov M, Maples B, et al.
Proc Natl Acad Sci U S A
. 2015 Dec;
113(4):E440-9.
PMID: 26712023
The Out-of-Africa (OOA) dispersal ∼ 50,000 y ago is characterized by a series of founder events as modern humans expanded into multiple continents. Population genetics theory predicts an increase of...
3.
Prufer K, Racimo F, Patterson N, Jay F, Sankararaman S, Sawyer S, et al.
Nature
. 2013 Dec;
505(7481):43-9.
PMID: 24352235
We present a high-quality genome sequence of a Neanderthal woman from Siberia. We show that her parents were related at the level of half-siblings and that mating among close relatives...
4.
Pimenoff V, Laval G, Comas D, Palo J, Gut I, Cann H, et al.
Pharmacogenet Genomics
. 2012 Oct;
22(12):846-57.
PMID: 23089684
Objective: Linkage disequilibrium (LD) and recombination rate variations are known to vary considerably between human genome regions and populations mostly because of the combined effects of mutation, recombination, and demographic...
5.
Leutenegger A, Sahbatou M, Gazal S, Cann H, Genin E
Eur J Hum Genet
. 2011 Mar;
19(5):583-7.
PMID: 21364699
Inbreeding coefficients and consanguineous mating types are usually inferred from population surveys or pedigree studies. Here, we present a method to estimate them from dense genome-wide single-nucleotide polymorphism genotypes and...
6.
Li R, Li Y, Zheng H, Luo R, Zhu H, Li Q, et al.
Nat Biotechnol
. 2009 Dec;
28(1):57-63.
PMID: 19997067
Here we integrate the de novo assembly of an Asian and an African genome with the NCBI reference human genome, as a step toward constructing the human pan-genome. We identified...
7.
Chen Y, Kraft P, Bretsky P, Ketkar S, Hunter D, Albanes D, et al.
Cancer Epidemiol Biomarkers Prev
. 2007 Oct;
16(10):1973-81.
PMID: 17932344
Background: Estrogen receptor beta (ESR2) may play a role in modulating prostate carcinogenesis through the regulation of genes related to cell proliferation and apoptosis. Methods: We conducted nested case-control studies...
8.
Gonzalez-Neira A, Ke X, Lao O, Calafell F, Navarro A, Comas D, et al.
Genome Res
. 2006 Feb;
16(3):323-30.
PMID: 16467560
In the search for common genetic variants that contribute to prevalent human diseases, patterns of linkage disequilibrium (LD) among linked markers should be considered when selecting SNPs. Genotyping efficiency can...
9.
Kraft P, Pharoah P, Chanock S, Albanes D, Kolonel L, Hayes R, et al.
PLoS Genet
. 2005 Nov;
1(5):e68.
PMID: 16311626
Steroid hormones are believed to play an important role in prostate carcinogenesis, but epidemiological evidence linking prostate cancer and steroid hormone genes has been inconclusive, in part due to small...
10.
Gonzalez-Neira A, Calafell F, Navarro A, Lao O, Cann H, Comas D, et al.
Hum Genomics
. 2004 Dec;
1(6):399-409.
PMID: 15606995
Recent studies of haplotype diversity in a number of genomic regions have suggested that long stretches of DNA are preserved in the same chromosome, with little evidence of recombination events....