Howard B Gutstein
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Explore the profile of Howard B Gutstein including associated specialties, affiliations and a list of published articles.
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39
Citations
556
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Recent Articles
1.
Puig S, Gutstein H
Neuroscience
. 2023 Mar;
519:147-161.
PMID: 36997020
The analgesic effect of opioids decreases over time due to the development of analgesic tolerance. We have shown that inhibition of the platelet-derived growth factor beta (PDGFR-β) signaling eliminates morphine...
2.
Monroe L, Johnson J, Gutstein H, Lawrence J, LeJeune K, Sullivan R, et al.
PLoS One
. 2022 Sep;
17(9):e0273194.
PMID: 36137079
Severe viral respiratory diseases, such as SARS-CoV-2, are transmitted through aerosol particles produced by coughing, talking, and breathing. Medical procedures including tracheal intubation, extubation, dental work, and any procedure involving...
3.
Barker K, Lecznar A, Schumacher J, Morris J, Gutstein H
J Neurosci Res
. 2021 Sep;
100(1):149-164.
PMID: 34520585
Opioids are commonly used for the treatment of postoperative and post-traumatic pain; however, their therapeutic effectiveness is limited by undesirable and life-threatening side effects. Researchers have long attempted to develop...
4.
de Villalobos D, Laserna A, Fowler C, Cuenca J, Martin P, Guindani M, et al.
Anaesthesiol Intensive Ther
. 2021 Jul;
53(3):223-231.
PMID: 34284554
Introduction: Although humans are capable of enduring critically low levels of oxygen, many hypoxaemic patients die despite aggressive therapies. Mimicking the physiological hyperventilation necessary to survive extreme hypoxic conditions could...
5.
Bailes A, Navlani R, Koscumb S, Malecky A, Marroquin O, Wasan A, et al.
Spine J
. 2021 Mar;
21(9):1440-1449.
PMID: 33785473
Background Context: Psychological comorbidities are important prognostic factors for low back pain (LBP). To develop improved treatment paradigms, it is first necessary to characterize and determine current patterns of treatment...
6.
Wang Y, Wang J, Xia S, Gutstein H, Huang Y, Schluter O, et al.
Pain
. 2020 Nov;
162(5):1322-1333.
PMID: 33230002
Pain experience can change the central processing of nociceptive inputs, resulting in persistent allodynia and hyperalgesia. However, the underlying circuit mechanisms remain underexplored. Here, we focus on pain-induced remodeling of...
7.
Puig S, Donica C, Gutstein H
eNeuro
. 2020 Mar;
7(2).
PMID: 32111605
The safety and efficacy of opioids are compromised as analgesic tolerance develops. Opioids are also ineffective against neuropathic pain. Recent reports have suggested that inhibitors of the epidermal growth factor...
8.
Lopez-Bellido R, Himmel N, Gutstein H, Cox D, Galko M
Philos Trans R Soc Lond B Biol Sci
. 2019 Sep;
374(1785):20190282.
PMID: 31544619
Chemically induced nociception has not yet been studied intensively in genetically tractable models. Hence, our goal was to establish a assay that can be used to study the cellular and...
9.
Lopez-Bellido R, Puig S, Huang P, Tsai C, Turner H, Galko M, et al.
J Neurosci
. 2019 May;
39(30):6012-6030.
PMID: 31138657
Mechanical sensitization is one of the most difficult clinical pain problems to treat. However, the molecular and genetic bases of mechanical nociception are unclear. Here we develop a model of...
10.
Barkai O, Puig S, Lev S, Title B, Katz B, Eli-Berchoer L, et al.
Pain
. 2019 Apr;
160(6):1281-1296.
PMID: 30933959
Endogenous inflammatory mediators contribute to the pathogenesis of pain by acting on nociceptors, specialized sensory neurons that detect noxious stimuli. Here, we describe a new factor mediating inflammatory pain. We...