Hong-Wen Tang
Overview
Explore the profile of Hong-Wen Tang including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
620
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0
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Recent Articles
11.
Cho S, Lee G, Pickering B, Jang C, Park J, He L, et al.
Mol Cell
. 2021 Mar;
81(10):2064-2075.e8.
PMID: 33756105
Dysregulated mTORC1 signaling alters a wide range of cellular processes, contributing to metabolic disorders and cancer. Defining the molecular details of downstream effectors is thus critical for uncovering selective therapeutic...
12.
Tang H, Weng J, Lee W, Hu Y, Gu L, Cho S, et al.
Proc Natl Acad Sci U S A
. 2021 Mar;
118(10).
PMID: 33649236
Mechanistic Target of Rapamycin Complex 1 (mTORC1) is a central regulator of cell growth and metabolism that senses and integrates nutritional and environmental cues with cellular responses. Recent studies have...
13.
Chen Y, Huang T, Lin Y, Lin S, Li W, Hsiao H, et al.
Nat Commun
. 2021 Feb;
12(1):1322.
PMID: 33637724
The ubiquitin-proteasome system (UPS) and autophagy are two major quality control processes whose impairment is linked to a wide variety of diseases. The coordination between UPS and autophagy remains incompletely...
14.
Wang W, Li J, Tan J, Wang M, Yang J, Zhang Z, et al.
Nat Commun
. 2021 Jan;
12(1):476.
PMID: 33473107
Endonuclease G (ENDOG), a mitochondrial nuclease, is known to participate in many cellular processes, including apoptosis and paternal mitochondrial elimination, while its role in autophagy remains unclear. Here, we report...
15.
Gu L, Wang L, Chen H, Hong J, Shen Z, Dhall A, et al.
Cell Discov
. 2020 Jul;
6:44.
PMID: 32637152
No abstract available.
16.
Bajpai A, Quazi T, Tang H, Manzar N, Singh V, Thakur A, et al.
Dis Model Mech
. 2020 Jun;
13(7).
PMID: 32540914
Peptide therapeutics, unlike small-molecule drugs, display crucial advantages of target specificity and the ability to block large interacting interfaces, such as those of transcription factors. The transcription co-factor of the...
17.
Xu C, Franklin B, Tang H, Regimbald-Dumas Y, Hu Y, Ramos J, et al.
Proc Natl Acad Sci U S A
. 2019 Dec;
117(1):464-471.
PMID: 31852821
Metabolites are increasingly appreciated for their roles as signaling molecules. To dissect the roles of metabolites, it is essential to understand their signaling pathways and their enzymatic regulations. From an...
18.
Xu C, Tang H, Hung R, Hu Y, Ni X, Housden B, et al.
Cell Rep
. 2019 Jan;
26(3):670-688.e6.
PMID: 30650359
Hippo signaling and the activity of its transcriptional coactivator, Yorkie (Yki), are conserved and crucial regulators of tissue homeostasis. In the Drosophila midgut, after tissue damage, Yki activity increases to...
19.
Song W, Kir S, Hong S, Hu Y, Wang X, Binari R, et al.
Dev Cell
. 2019 Jan;
48(2):277-286.e6.
PMID: 30639055
Interactions between tumors and host tissues play essential roles in tumor-induced systemic wasting and cancer cachexia, including muscle wasting and lipid loss. However, the pathogenic molecular mechanisms of wasting are...
20.
Tang H, Hu Y, Chen C, Xia B, Zirin J, Yuan M, et al.
Cell Metab
. 2018 Apr;
27(5):1040-1054.e8.
PMID: 29606597
Nutrient deprivation induces autophagy through inhibiting TORC1 activity. We describe a novel mechanism in Drosophila by which TORC1 regulates RNA processing of Atg transcripts and alters ATG protein levels and...