Holly E Humphries
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Explore the profile of Holly E Humphries including associated specialties, affiliations and a list of published articles.
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20
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1537
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Recent Articles
11.
Ryan K, Bewley K, Fotheringham S, Slack G, Brown P, Hall Y, et al.
Nat Commun
. 2021 Jan;
12(1):81.
PMID: 33398055
There is a vital need for authentic COVID-19 animal models to enable the pre-clinical evaluation of candidate vaccines and therapeutics. Here we report a dose titration study of SARS-CoV-2 in...
12.
Humphries H, Brookes C, Allen L, Kuisma E, Gorringe A, Taylor S
Clin Vaccine Immunol
. 2015 Mar;
22(5):503-9.
PMID: 25739917
The correlate of protection for the licensure of meningococcal vaccines is serum bactericidal activity. However, evidence indicates that a complex situation and other mechanisms, such as antibody-mediated, complement-dependent opsonophagocytosis (OP),...
13.
Williams J, Skipp P, Humphries H, Christodoulides M, OConnor C, Heckels J
Infect Immun
. 2006 Dec;
75(3):1364-72.
PMID: 17158897
Current experimental vaccines against serogroup B Neisseria meningitidis are based on meningococcal outer membrane (OM) proteins present in outer membrane vesicles (OMV) in which toxic lipopolysaccharide is depleted by detergent...
14.
Fowler M, Yin K, Humphries H, Heckels J, Christodoulides M
Infect Immun
. 2006 Sep;
74(11):6467-78.
PMID: 16954390
The rationale for the present study was to determine how different species of bacteria interact with cells of the human meninges in order to gain information that would have broad...
15.
Humphries H, Williams J, Blackstone R, Jolley K, Yuen H, Christodoulides M, et al.
Vaccine
. 2005 Aug;
24(1):36-44.
PMID: 16105711
Four serosubtypes (P1.7, 16, P1.7-2, 4, P1.19, 15 and P1.5-1, 10-4) of the PorA outer-membrane protein of Neisseria meningitidis were purified as recombinant proteins and incorporated into liposomes to investigate...
16.
Humphries H, Triantafilou M, Makepeace B, Heckels J, Triantafilou K, Christodoulides M
Cell Microbiol
. 2005 Feb;
7(3):415-30.
PMID: 15679844
The interactions of Neisseria meningitidis with cells of the meninges are critical to progression of the acute, compartmentalized intracranial inflammatory response that is characteristic of meningococcal meningitis. An important virulence...
17.
Al-Bader T, Jolley K, Humphries H, Holloway J, Heckels J, Semper A, et al.
Cell Microbiol
. 2004 Jun;
6(7):651-62.
PMID: 15186401
The major porin proteins present in the outer membrane of Neisseria meningitidis, the causative agent of life-threatening meningitis and septicaemia, are believed to have potent immunostimulatory effects. In this study,...
18.
Humphries H, Williams J, Christodoulides M, Heckels J
Vaccine
. 2004 Apr;
22(11-12):1564-9.
PMID: 15063582
The PorA protein of Neisseria meningitidis (subtype P1.7,16) was expressed as a recombinant protein using three vectors; pTWIN, pQE30 and pRSETA, which introduce different sized N-terminal leader sequences to the...
19.
Humphries H, High N
FEMS Immunol Med Microbiol
. 2002 Nov;
34(3):221-30.
PMID: 12423775
LicA encodes the enzyme phosphorylcholine kinase which catalyses the incorporation of phosphorylcholine (ChoP) into H. influenzae LPS. Expression of this gene is subject to phase variation, resulting in the spontaneous...
20.
Humphries H, Christodoulides M, Heckels J
Protein Expr Purif
. 2002 Oct;
26(2):243-8.
PMID: 12406678
The class 1 protein (PorA) is a major component of the outer membrane of Neisseria meningitidis and functions as a cationic porin. The protein is particularly effective in generating a...