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Holger Klein

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Articles 43
Citations 486
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Recent Articles
11.
Strobel B, Klein H, Leparc G, Stierstorfer B, Gantner F, Kreuz S
Sci Rep . 2022 Jul; 12(1):12190. PMID: 35842487
We have previously established a novel mouse model of lung fibrosis based on Adeno-associated virus (AAV)-mediated pulmonary overexpression of TGFβ1. Here, we provide an in-depth characterization of phenotypic and transcriptomic...
12.
Dong H, Sun W, Shen Y, Balaz M, Balazova L, Ding L, et al.
Nat Metab . 2022 Jan; 4(1):90-105. PMID: 35027768
Healthy adipose tissue remodeling depends on the balance between de novo adipogenesis from adipogenic progenitor cells and the hypertrophy of adipocytes. De novo adipogenesis has been shown to promote healthy...
13.
Van Hemelrijck M, Frank M, Zinkernagel A, Buechel R, Sromicki J, Wilhelm M, et al.
Indian J Thorac Cardiovasc Surg . 2021 Sep; 37(5):573-576. PMID: 34511767
Fungal osteomyelitis is an uncommon complication after cardiac surgery and associated with high mortality. A case of and osteomyelitis with device infection after implantation of a left ventricular assist device...
14.
Becker K, Klein H, Simon E, Viollet C, Haslinger C, Leparc G, et al.
Sci Rep . 2021 May; 11(1):10494. PMID: 34006945
Diabetic Retinopathy (DR) is among the major global causes for vision loss. With the rise in diabetes prevalence, an increase in DR incidence is expected. Current understanding of both the...
15.
Hofmaenner D, Steiger P, Schuepbach R, Klinzing S, Waldner M, Klein H, et al.
Burns . 2020 Nov; 47(4):796-804. PMID: 33143989
Objectives: Bromelain-based enzymatic debridement has emerged as an alternative to surgical eschar removal. Indications include partial thickness, mixed pattern, and full-thickness burns. Enzymatic debridement has been approved by the European...
16.
Klein H, Kodjikian S, Philippe R, Ding L, Colin C, Darie C, et al.
Acta Crystallogr B Struct Sci Cryst Eng Mater . 2020 Oct; 76(Pt 5):727-732. PMID: 33017306
In the framework of expanding the range of copper-based compounds in the pyroxene family, we have synthesized at high pressure and high temperature a powder containing a mixture of a...
17.
Chae H, Augustin R, Gatineau E, Mayoux E, Bensellam M, Antoine N, et al.
Mol Metab . 2020 Sep; 42:101071. PMID: 32896668
Objective: Sodium-glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i), or gliflozins, are anti-diabetic drugs that lower glycemia by promoting glucosuria, but they also stimulate endogenous glucose and ketone body production. The likely...
18.
Klein H, Garlea V, Darie C, Bordet P
Acta Crystallogr B Struct Sci Cryst Eng Mater . 2020 Aug; 75(Pt 1):107-112. PMID: 32830784
In the search for frustrated spin interactions, a YCuO phase has been synthesized by a treatment under oxygen pressure of YCuO. X-ray powder diffraction and electron diffraction studies have been...
19.
Strobel B, Sporing M, Klein H, Blazevic D, Rust W, Sayols S, et al.
Nat Commun . 2020 Feb; 11(1):714. PMID: 32024835
Synthetic riboswitches mediating ligand-dependent RNA cleavage or splicing-modulation represent elegant tools to control gene expression in various applications, including next-generation gene therapy. However, due to the limited understanding of context-dependent...
20.
Kodjikian S, Klein H
Ultramicroscopy . 2019 Feb; 200:12-19. PMID: 30797182
A new electron diffraction tomography method is presented that is aimed to enable high performance electron crystallography experiments on beam sensitive materials using a standard TEM without any special equipment....