Hoi-Kei Lon
Overview
Explore the profile of Hoi-Kei Lon including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
176
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0
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Recent Articles
11.
Liu D, Lon H, Wang Y, DuBois D, Almon R, Jusko W
Biopharm Drug Dispos
. 2013 Mar;
34(4):203-14.
PMID: 23456770
Methotrexate (MTX) is an anchor drug used to treat rheumatoid arthritis (RA), but responsiveness is variable in effectiveness and toxicity. Methotrexate and its polyglutamate conjugates (MTXPG(n)) in red blood cells...
12.
Lon H, Liu D, Jusko W
Crit Rev Biomed Eng
. 2012 Nov;
40(4):295-312.
PMID: 23140121
Inflammation is an array of immune responses to infection and injury. It results from a complex immune cascade and is the basis of many chronic diseases such as arthritis, diabetes,...
13.
Liu D, Lon H, DuBois D, Almon R, Jusko W
J Pharmacokinet Pharmacodyn
. 2011 Oct;
38(6):769-86.
PMID: 22002845
A population pharmacokinetic-pharmacodynamic-disease progression (PK/PD/DIS) model was developed to characterize the effects of anakinra in collagen-induced arthritic (CIA) rats and explore the role of interleukin-1β (IL-1β) in rheumatoid arthritis. The...
14.
Lon H, Liu D, Zhang Q, DuBois D, Almon R, Jusko W
Pharm Res
. 2011 Mar;
28(7):1622-30.
PMID: 21360252
Purpose: To develop a pharmacokinetic-pharmacodynamic disease progression (PK/PD/DIS) model to characterize the effect of etanercept in collagen-induced arthritis (CIA) rats on rheumatoid arthritis (RA) progression. Methods: The CIA rats received...
15.
Felmlee M, Lon H, Gonzalez F, Yu A
Drug Metab Dispos
. 2007 Dec;
36(2):435-41.
PMID: 18048490
Analysis of the developmental and sexual expression of cytochrome P450 drug-metabolizing enzymes is impeded by multiple and varied external factors that influence its regulation. In the present study, a CYP2D6/CYP3A4-double...